In the brain, microvascular endothelial cells are sealed together by continuous tight junctions and contain few pinocytotic vesicles. These features underlie formation of the blood-brain barrier (BBB) which markedly restricts the free diffusion of water soluble molecules between the plasma and interstitial fluid of the nervous system. These studies document the usefulness of endothelial cells in culture to investigate function of the blood-brain barrier. One of the goals is to establish a proper permeable support matrix upon which to investigate the transcellular movement of organic molecules and ions known to permeate the intact blood-brain barrier.
|Original language||English (US)|
|Title of host publication||American Chemical Society, Polymer Preprints, Division of Polymer Chemistry|
|Editors||Bill M. Culbertson, Judith S. Riffle, Frank D. Blum, Harry W. Gibson|
|Number of pages||1|
|Publication status||Published - Sep 1986|
ASJC Scopus subject areas
- Polymers and Plastics