In Vitro Sensitivity of Measles Virus to 6-Azauridine

Larry L. Leonard, Volker Ter Meulen, John M. Freeman

Research output: Contribution to journalArticle

Abstract

The effect of 6-azauridine, an inhibitor of RNA synthesis, has been shown by 2 experimental methods to inhibit the replication of measles virus within mammalian cells in vitro. In a direct virus titration in which the drug was incorporated in the agar overlay, 6-AZ not only reduced the infectivity of measles virus but also delayed plaque development. Experiments designed to test the effectiveness of 6-azauridine when added to cultures at intervals after infection, showed that this uridine analog was capable of reducing the amount of infectious virus produced by each infected cell, and that the drug is more effective when added early in the infection cycle.

Original languageEnglish (US)
Pages (from-to)857-862
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume136
Issue number3
DOIs
StatePublished - Mar 1971

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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