In vitro reversal of indomethacin-blocked ovulation by prostaglandin F(2α)

Y. Hamada, K. H. Wright, Edward E Wallach

Research output: Contribution to journalArticle

Abstract

An in vitro perfused ovary preparation was used to study the role of prostaglandin F(2α) (PGF(2α))in follicle rupture. The administration of PGF(2α) alone has been shown to restore indomethacin-blocked ovulation in rabbits and monkeys. In the model used, ovulation consistently occurred when human chorionic gonadotropin (hCG) was given to the intact rabbit prior to ovarian removal. hCG-induced ovulation was blocked in both perfused and in situ control ovaries by indomethacin (10 mg/kg IV 6 hr after hCG) given to the intact animal. The addition of PGF(2α)(1 mg/200 ml) to the perfusion fluid restored ovulation in the isolated ovary as compared with the in situ ovary (P

Original languageEnglish (US)
Pages (from-to)702-706
Number of pages5
JournalFertility and Sterility
Volume30
Issue number6
StatePublished - 1978
Externally publishedYes

Fingerprint

Prostaglandins F
Ovulation
Indomethacin
Ovary
Chorionic Gonadotropin
Rabbits
Haplorhini
Rupture
Perfusion
In Vitro Techniques

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

In vitro reversal of indomethacin-blocked ovulation by prostaglandin F(2α). / Hamada, Y.; Wright, K. H.; Wallach, Edward E.

In: Fertility and Sterility, Vol. 30, No. 6, 1978, p. 702-706.

Research output: Contribution to journalArticle

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