In vitro precipitation of calcium oxalate in the presence of whole matrix or lipid components of the urinary stones

S. R. Khan, P. N. Shevock, R. L. Hackett

Research output: Contribution to journalArticle

Abstract

Organic matrix of human calcium oxalate urinary stones was obtained by demineralizing with EDTA. Lipids were extracted from the EDTA-insoluble matrix by chloroform methanol treatment. The whole matrix and its total lipid extract were then incubated in a metastable solution of calcium oxalate and depletion of calcium and oxalate ions from the calcifying solution was determined. Results of our studies described here show that urinary calcium oxalate stone matrix and its total lipid contents were capable of binding calcium and oxalate ions and of catalysing calcium oxalate crystal formation from a metastable calcium oxalate solution.

Original languageEnglish (US)
Pages (from-to)418-422
Number of pages5
JournalJournal of Urology
Volume139
Issue number2
Publication statusPublished - 1988
Externally publishedYes

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ASJC Scopus subject areas

  • Urology

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