In vitro polymerization of oxidized tau into filaments

Juan C Troncoso, Anthony Costello, Arthur L. Watson, Gail V W Johnson

Research output: Contribution to journalArticle

Abstract

Paired helical filaments (PHF) are abnormal neuronal polymers characteristic of Alzheimer's disease (AD). Although tau appears to be a major constituent of PHF, the mechanism for the polymerization of tau or its integration into PHF remains unknown. Here, we show that the oxidation of bovine tau in vitro induces an apparent dimerization of this protein and polymerization into filaments. These observations suggest that the oxidation of tau in vivo may contribute to the development of PHF in individuals with AD.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalBrain Research
Volume613
Issue number2
DOIs
Publication statusPublished - Jun 11 1993

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Keywords

  • Ageing
  • Alzheimer's disease
  • Cytoskeleton
  • Oxidation
  • Tau

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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