In vitro polymerization of oxidized tau into filaments

Juan C. Troncoso; Anthony Costello; Arthur L. Watson; Gail V.W. Johnson

doi:10.1016/0006-8993(93)90918-D

In vitro polymerization of oxidized tau into filaments

Juan C. Troncoso, Anthony Costello, Arthur L. Watson, Gail V.W. Johnson

School of Medicine

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Paired helical filaments (PHF) are abnormal neuronal polymers characteristic of Alzheimer's disease (AD). Although tau appears to be a major constituent of PHF, the mechanism for the polymerization of tau or its integration into PHF remains unknown. Here, we show that the oxidation of bovine tau in vitro induces an apparent dimerization of this protein and polymerization into filaments. These observations suggest that the oxidation of tau in vivo may contribute to the development of PHF in individuals with AD.

Original language	English (US)
Pages (from-to)	313-316
Number of pages	4
Journal	Brain research
Volume	613
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(93)90918-D
State	Published - Jun 11 1993

Keywords

Ageing
Alzheimer's disease
Cytoskeleton
Oxidation
Tau

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(93)90918-D

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title = "In vitro polymerization of oxidized tau into filaments",

abstract = "Paired helical filaments (PHF) are abnormal neuronal polymers characteristic of Alzheimer's disease (AD). Although tau appears to be a major constituent of PHF, the mechanism for the polymerization of tau or its integration into PHF remains unknown. Here, we show that the oxidation of bovine tau in vitro induces an apparent dimerization of this protein and polymerization into filaments. These observations suggest that the oxidation of tau in vivo may contribute to the development of PHF in individuals with AD.",

keywords = "Ageing, Alzheimer's disease, Cytoskeleton, Oxidation, Tau",

author = "Troncoso, {Juan C.} and Anthony Costello and Watson, {Arthur L.} and Johnson, {Gail V.W.}",

note = "Funding Information: The authors thank Dr. Kenneth Kosik for reviewing the manuscript. This work was supported by grants from the US Public Health Service (AG 05146, NS 25369, NS 27538, AG 06569) and the American Health Assistance Foundation.",

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T1 - In vitro polymerization of oxidized tau into filaments

AU - Troncoso, Juan C.

AU - Costello, Anthony

AU - Watson, Arthur L.

AU - Johnson, Gail V.W.

N1 - Funding Information: The authors thank Dr. Kenneth Kosik for reviewing the manuscript. This work was supported by grants from the US Public Health Service (AG 05146, NS 25369, NS 27538, AG 06569) and the American Health Assistance Foundation.

PY - 1993/6/11

Y1 - 1993/6/11

N2 - Paired helical filaments (PHF) are abnormal neuronal polymers characteristic of Alzheimer's disease (AD). Although tau appears to be a major constituent of PHF, the mechanism for the polymerization of tau or its integration into PHF remains unknown. Here, we show that the oxidation of bovine tau in vitro induces an apparent dimerization of this protein and polymerization into filaments. These observations suggest that the oxidation of tau in vivo may contribute to the development of PHF in individuals with AD.

AB - Paired helical filaments (PHF) are abnormal neuronal polymers characteristic of Alzheimer's disease (AD). Although tau appears to be a major constituent of PHF, the mechanism for the polymerization of tau or its integration into PHF remains unknown. Here, we show that the oxidation of bovine tau in vitro induces an apparent dimerization of this protein and polymerization into filaments. These observations suggest that the oxidation of tau in vivo may contribute to the development of PHF in individuals with AD.

KW - Ageing

KW - Alzheimer's disease

KW - Cytoskeleton

KW - Oxidation

KW - Tau

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ER -

In vitro polymerization of oxidized tau into filaments

Abstract

Keywords

ASJC Scopus subject areas

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