In vitro neutralization of HSV‐2: Inhibition by binding of normal IgG and purified Fc to virion Fc receptor (FcR)

Kenneth W. Dowler, Robert W. Veltri

Research output: Contribution to journalArticle

Abstract

We designed experiments to assess the effects of binding of the HSV‐2 Fc receptor (FcR) to purified rabbit nonimmune IgG and purified Fc. Purified Fc (75 μg) or nonimmune IgG (100 μg) when bound to HSV‐2 did not reduce infectivity but did protect the virions against thermal inactivation at 37°C. However, preincubation of these two reagents with HSV‐2 virions significantly protected against neutralization by specific anti‐HSV‐2, F(ab')2 purified rabbit antiserum. The blockage of neutralization and protection against thermal inactivation afforded by FcR‐Fc interaction on HSV‐2 virions provide a tenable mechanism to explain viral persistence in an immune host.

Original languageEnglish (US)
Pages (from-to)251-259
Number of pages9
JournalJournal of Medical Virology
Volume13
Issue number3
DOIs
StatePublished - 1984

Keywords

  • Fc receptor
  • antiviral F(ab')
  • herpes simplex virus
  • neutralization

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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