IN VITRO MODELS FOR THE EVALUATION OF TOXICITY AND CARCINOGENESIS.

The reasons for developing in vitro techniques in toxicology are discussed. Several areas are then explored, by way of example, to demonstrate how in vitro methodology can be applied in the study of inflammation and hepatotoxicity and in the development of methods appropriate for studying carcinogenesis and therapeutic approaches to cancer. It is suggested that human specific proteins may be necessary for the acceptance of in vitro methodology in toxicology.