In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin

Lorraine Jones-Brando; John D'Angelo; Gary H. Posner; Robert Yolken

doi:10.1128/AAC.00793-06

In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin

Lorraine Jones-Brando, John D'Angelo, Gary H. Posner, Robert Yolken

School of Medicine

Research output: Contribution to journal › Article

Abstract

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.

Original language	English (US)
Pages (from-to)	4206-4208
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	50
Issue number	12
DOIs	https://doi.org/10.1128/AAC.00793-06
State	Published - Dec 1 2006

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ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

Cite this

Jones-Brando, L., D'Angelo, J., Posner, G. H., & Yolken, R. (2006). In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin. Antimicrobial agents and chemotherapy, 50(12), 4206-4208. https://doi.org/10.1128/AAC.00793-06

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Access to Document

10.1128/AAC.00793-06