In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin

Lorraine Jones-Brando, John D'Angelo, Gary H. Posner, Robert Yolken

Research output: Contribution to journalArticlepeer-review

Abstract

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.

Original languageEnglish (US)
Pages (from-to)4206-4208
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume50
Issue number12
DOIs
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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