TY - JOUR
T1 - In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin
AU - Jones-Brando, Lorraine
AU - D'Angelo, John
AU - Posner, Gary H.
AU - Yolken, Robert
PY - 2006/12
Y1 - 2006/12
N2 - Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.
AB - Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.
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U2 - 10.1128/AAC.00793-06
DO - 10.1128/AAC.00793-06
M3 - Article
C2 - 17060514
AN - SCOPUS:33845268199
VL - 50
SP - 4206
EP - 4208
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 12
ER -