In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin

Lorraine V Brando, John D'Angelo, Gary H. Posner, Robert H Yolken

Research output: Contribution to journalArticle

Abstract

Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.

Original languageEnglish (US)
Pages (from-to)4206-4208
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number12
DOIs
StatePublished - Dec 2006

Fingerprint

Toxoplasma
Toxoplasmosis
Cell Culture Techniques
In Vitro Techniques
artemisinine

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin. / Brando, Lorraine V; D'Angelo, John; Posner, Gary H.; Yolken, Robert H.

In: Antimicrobial Agents and Chemotherapy, Vol. 50, No. 12, 12.2006, p. 4206-4208.

Research output: Contribution to journalArticle

@article{83aeb56cb89c4b8d95ad5510e145da2b,
title = "In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin",
abstract = "Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.",
author = "Brando, {Lorraine V} and John D'Angelo and Posner, {Gary H.} and Yolken, {Robert H}",
year = "2006",
month = "12",
doi = "10.1128/AAC.00793-06",
language = "English (US)",
volume = "50",
pages = "4206--4208",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "12",

}

TY - JOUR

T1 - In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin

AU - Brando, Lorraine V

AU - D'Angelo, John

AU - Posner, Gary H.

AU - Yolken, Robert H

PY - 2006/12

Y1 - 2006/12

N2 - Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.

AB - Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is medically important and distributed worldwide. Currently available medications are limited in terms of efficacy and side effects. We synthesized novel, nonacetal, hydrolytically stable derivatives of artemisinin and showed that they inhibit the replication of Toxoplasma gondii in cell culture.

UR - http://www.scopus.com/inward/record.url?scp=33845268199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845268199&partnerID=8YFLogxK

U2 - 10.1128/AAC.00793-06

DO - 10.1128/AAC.00793-06

M3 - Article

C2 - 17060514

AN - SCOPUS:33845268199

VL - 50

SP - 4206

EP - 4208

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 12

ER -