In vitro fertilization and the cloacal/bladder exstrophy-epispadias complex: A continuing association

Hadley M. Wood, Denise Babineau, John P. Gearhart

Research output: Contribution to journalArticle

Abstract

Objective: To expand on a previously published analysis of children fertilized in vitro (IVF) who demonstrate the cloacal/bladder exstrophy-epispadias complex (CBEEC). Patients and methods: Data were collected on CBEEC patients who were fertilized in vitro and seen at The Brady Urological Institute of The Johns Hopkins Hospital (Brady/JHH) from 1997 to 2004. The numbers of live births and IVF births were acquired/estimated from the US Centers for Disease Control. Incidence rates for CBEEC were estimated using International Clearinghouse for Birth Defects Monitoring Systems data. A Pearson-type chi-squared analysis evaluated the association between IVF and CBEEC. Results: An estimated 322,937 IVF births occurred in the US in 1997-2004. The rate of CBEEC was estimated at 6.2:100,000. A total of 150 CBEEC patients born in 1997-2004 were evaluated at Brady/JHH of whom eight were IVF. Under the hypothesis of no association between IVF and CBEEC, the expected incidence of IVF in CBEEC children ranged between 0.60% and 1.59%. The observed incidence of IVF in CBEEC children evaluated at Brady/JHH ranged between 4.2% and 6.7%. Comparison of the expected and observed incidence using a Pearson-type chi-squared test resulted in a bootstrapped P value of 0.0182. Conclusion: The incidence of IVF in CBEEC children appears to be higher than what would be expected if there was no association between IVF and CBEEC.

Original languageEnglish (US)
Pages (from-to)305-310
Number of pages6
JournalJournal of pediatric urology
Volume3
Issue number4
DOIs
StatePublished - Aug 1 2007

Keywords

  • Birth defect
  • Epispadias
  • Exstrophy
  • IVF
  • In vitro fertilization

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Urology

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