In vitro fertilization and risk of childhood leukemia in Greece and Sweden

Eleni Th Petridou, Theodoros N. Sergentanis, Paraskevi Panagopoulou, Maria Moschovi, Sophia Polychronopoulou, Margarita Baka, Apostolos Pourtsidis, Fani Athanassiadou, Maria Kalmanti, Vasiliki Sidi, Nick Dessypris, Constantine Frangakis, Ioannis L. Matsoukis, Christodoulos Stefanadis, Alkistis Skalkidou, Olof Stephansson, Hans Olov Adami, Helle Kieler

Research output: Contribution to journalArticle

Abstract

Background: Cancer risk in children born after in vitro fertilization (IVF) remains largely unknown. We aimed to investigate risk of leukemia and lymphoma following IVF using two nationwide datasets. Methods: The hospital-based case-control study in Greece derived from the National Registry for Childhood Hematological Malignancies (1996-2008, 814 leukemia and 277 lymphoma incident cases with their 1:1 matched controls). The Swedish case-control study was nested in the Swedish Medical Birth Register (MBR) (1995-2007, 520 leukemia and 71 lymphoma cases with their 5,200 and 710 matched controls) with ascertainment of incident cancer cases in the National Cancer Register. Study-specific and combined odds ratios (OR) were estimated using conditional logistic regression, with adjustment for possible risk factors. Results: Nationwide studies pointed to similar size excess risk of leukemia following IVF, but to a null association between IVF and lymphoma. The proportion of leukemia cases conceived through IVF was 3% in Greece and 2.7% in Sweden; prevalence of IVF in matched controls was 1.8% and 1.6%, respectively. In combined multivariable analyses, the increased risk of leukemia was confined to age below 3.8 years (OR=2.21; 95% confidence interval, CI: 1.27-3.85) and to acute lymphoblastic leukemia (ALL) (OR=1.77; 95% CI: 1.06-2.95) with no sufficient evidence of excess risk for other leukemias (OR=1.34; 95% CI: 0.38-4.69). Following IVF, OR for ALL was 2.58 (95% CI: 1.37-4.84) before age 3.8 and 4.29 (95% CI: 1.49-12.37) before age 2 years. Conclusions: IVF seems to be associated with increased risk of early onset ALL in the offspring.

Original languageEnglish (US)
Pages (from-to)930-936
Number of pages7
JournalPediatric Blood and Cancer
Volume58
Issue number6
DOIs
StatePublished - Jun 2012

Fingerprint

Greece
Fertilization in Vitro
Sweden
Leukemia
Odds Ratio
Lymphoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Case-Control Studies
Neoplasms
Hematologic Neoplasms
Registries
Logistic Models
Parturition
Confidence Intervals

Keywords

  • Acute lymphoblastic leukemia
  • Assisted reproductive technologies
  • Childhood cancer
  • Risk factor

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

Cite this

Petridou, E. T., Sergentanis, T. N., Panagopoulou, P., Moschovi, M., Polychronopoulou, S., Baka, M., ... Kieler, H. (2012). In vitro fertilization and risk of childhood leukemia in Greece and Sweden. Pediatric Blood and Cancer, 58(6), 930-936. https://doi.org/10.1002/pbc.23194

In vitro fertilization and risk of childhood leukemia in Greece and Sweden. / Petridou, Eleni Th; Sergentanis, Theodoros N.; Panagopoulou, Paraskevi; Moschovi, Maria; Polychronopoulou, Sophia; Baka, Margarita; Pourtsidis, Apostolos; Athanassiadou, Fani; Kalmanti, Maria; Sidi, Vasiliki; Dessypris, Nick; Frangakis, Constantine; Matsoukis, Ioannis L.; Stefanadis, Christodoulos; Skalkidou, Alkistis; Stephansson, Olof; Adami, Hans Olov; Kieler, Helle.

In: Pediatric Blood and Cancer, Vol. 58, No. 6, 06.2012, p. 930-936.

Research output: Contribution to journalArticle

Petridou, ET, Sergentanis, TN, Panagopoulou, P, Moschovi, M, Polychronopoulou, S, Baka, M, Pourtsidis, A, Athanassiadou, F, Kalmanti, M, Sidi, V, Dessypris, N, Frangakis, C, Matsoukis, IL, Stefanadis, C, Skalkidou, A, Stephansson, O, Adami, HO & Kieler, H 2012, 'In vitro fertilization and risk of childhood leukemia in Greece and Sweden', Pediatric Blood and Cancer, vol. 58, no. 6, pp. 930-936. https://doi.org/10.1002/pbc.23194
Petridou ET, Sergentanis TN, Panagopoulou P, Moschovi M, Polychronopoulou S, Baka M et al. In vitro fertilization and risk of childhood leukemia in Greece and Sweden. Pediatric Blood and Cancer. 2012 Jun;58(6):930-936. https://doi.org/10.1002/pbc.23194
Petridou, Eleni Th ; Sergentanis, Theodoros N. ; Panagopoulou, Paraskevi ; Moschovi, Maria ; Polychronopoulou, Sophia ; Baka, Margarita ; Pourtsidis, Apostolos ; Athanassiadou, Fani ; Kalmanti, Maria ; Sidi, Vasiliki ; Dessypris, Nick ; Frangakis, Constantine ; Matsoukis, Ioannis L. ; Stefanadis, Christodoulos ; Skalkidou, Alkistis ; Stephansson, Olof ; Adami, Hans Olov ; Kieler, Helle. / In vitro fertilization and risk of childhood leukemia in Greece and Sweden. In: Pediatric Blood and Cancer. 2012 ; Vol. 58, No. 6. pp. 930-936.
@article{223ca1920f214264ad72e89d00cae37e,
title = "In vitro fertilization and risk of childhood leukemia in Greece and Sweden",
abstract = "Background: Cancer risk in children born after in vitro fertilization (IVF) remains largely unknown. We aimed to investigate risk of leukemia and lymphoma following IVF using two nationwide datasets. Methods: The hospital-based case-control study in Greece derived from the National Registry for Childhood Hematological Malignancies (1996-2008, 814 leukemia and 277 lymphoma incident cases with their 1:1 matched controls). The Swedish case-control study was nested in the Swedish Medical Birth Register (MBR) (1995-2007, 520 leukemia and 71 lymphoma cases with their 5,200 and 710 matched controls) with ascertainment of incident cancer cases in the National Cancer Register. Study-specific and combined odds ratios (OR) were estimated using conditional logistic regression, with adjustment for possible risk factors. Results: Nationwide studies pointed to similar size excess risk of leukemia following IVF, but to a null association between IVF and lymphoma. The proportion of leukemia cases conceived through IVF was 3{\%} in Greece and 2.7{\%} in Sweden; prevalence of IVF in matched controls was 1.8{\%} and 1.6{\%}, respectively. In combined multivariable analyses, the increased risk of leukemia was confined to age below 3.8 years (OR=2.21; 95{\%} confidence interval, CI: 1.27-3.85) and to acute lymphoblastic leukemia (ALL) (OR=1.77; 95{\%} CI: 1.06-2.95) with no sufficient evidence of excess risk for other leukemias (OR=1.34; 95{\%} CI: 0.38-4.69). Following IVF, OR for ALL was 2.58 (95{\%} CI: 1.37-4.84) before age 3.8 and 4.29 (95{\%} CI: 1.49-12.37) before age 2 years. Conclusions: IVF seems to be associated with increased risk of early onset ALL in the offspring.",
keywords = "Acute lymphoblastic leukemia, Assisted reproductive technologies, Childhood cancer, Risk factor",
author = "Petridou, {Eleni Th} and Sergentanis, {Theodoros N.} and Paraskevi Panagopoulou and Maria Moschovi and Sophia Polychronopoulou and Margarita Baka and Apostolos Pourtsidis and Fani Athanassiadou and Maria Kalmanti and Vasiliki Sidi and Nick Dessypris and Constantine Frangakis and Matsoukis, {Ioannis L.} and Christodoulos Stefanadis and Alkistis Skalkidou and Olof Stephansson and Adami, {Hans Olov} and Helle Kieler",
year = "2012",
month = "6",
doi = "10.1002/pbc.23194",
language = "English (US)",
volume = "58",
pages = "930--936",
journal = "Pediatric Blood and Cancer",
issn = "1545-5009",
publisher = "Wiley-Liss Inc.",
number = "6",

}

TY - JOUR

T1 - In vitro fertilization and risk of childhood leukemia in Greece and Sweden

AU - Petridou, Eleni Th

AU - Sergentanis, Theodoros N.

AU - Panagopoulou, Paraskevi

AU - Moschovi, Maria

AU - Polychronopoulou, Sophia

AU - Baka, Margarita

AU - Pourtsidis, Apostolos

AU - Athanassiadou, Fani

AU - Kalmanti, Maria

AU - Sidi, Vasiliki

AU - Dessypris, Nick

AU - Frangakis, Constantine

AU - Matsoukis, Ioannis L.

AU - Stefanadis, Christodoulos

AU - Skalkidou, Alkistis

AU - Stephansson, Olof

AU - Adami, Hans Olov

AU - Kieler, Helle

PY - 2012/6

Y1 - 2012/6

N2 - Background: Cancer risk in children born after in vitro fertilization (IVF) remains largely unknown. We aimed to investigate risk of leukemia and lymphoma following IVF using two nationwide datasets. Methods: The hospital-based case-control study in Greece derived from the National Registry for Childhood Hematological Malignancies (1996-2008, 814 leukemia and 277 lymphoma incident cases with their 1:1 matched controls). The Swedish case-control study was nested in the Swedish Medical Birth Register (MBR) (1995-2007, 520 leukemia and 71 lymphoma cases with their 5,200 and 710 matched controls) with ascertainment of incident cancer cases in the National Cancer Register. Study-specific and combined odds ratios (OR) were estimated using conditional logistic regression, with adjustment for possible risk factors. Results: Nationwide studies pointed to similar size excess risk of leukemia following IVF, but to a null association between IVF and lymphoma. The proportion of leukemia cases conceived through IVF was 3% in Greece and 2.7% in Sweden; prevalence of IVF in matched controls was 1.8% and 1.6%, respectively. In combined multivariable analyses, the increased risk of leukemia was confined to age below 3.8 years (OR=2.21; 95% confidence interval, CI: 1.27-3.85) and to acute lymphoblastic leukemia (ALL) (OR=1.77; 95% CI: 1.06-2.95) with no sufficient evidence of excess risk for other leukemias (OR=1.34; 95% CI: 0.38-4.69). Following IVF, OR for ALL was 2.58 (95% CI: 1.37-4.84) before age 3.8 and 4.29 (95% CI: 1.49-12.37) before age 2 years. Conclusions: IVF seems to be associated with increased risk of early onset ALL in the offspring.

AB - Background: Cancer risk in children born after in vitro fertilization (IVF) remains largely unknown. We aimed to investigate risk of leukemia and lymphoma following IVF using two nationwide datasets. Methods: The hospital-based case-control study in Greece derived from the National Registry for Childhood Hematological Malignancies (1996-2008, 814 leukemia and 277 lymphoma incident cases with their 1:1 matched controls). The Swedish case-control study was nested in the Swedish Medical Birth Register (MBR) (1995-2007, 520 leukemia and 71 lymphoma cases with their 5,200 and 710 matched controls) with ascertainment of incident cancer cases in the National Cancer Register. Study-specific and combined odds ratios (OR) were estimated using conditional logistic regression, with adjustment for possible risk factors. Results: Nationwide studies pointed to similar size excess risk of leukemia following IVF, but to a null association between IVF and lymphoma. The proportion of leukemia cases conceived through IVF was 3% in Greece and 2.7% in Sweden; prevalence of IVF in matched controls was 1.8% and 1.6%, respectively. In combined multivariable analyses, the increased risk of leukemia was confined to age below 3.8 years (OR=2.21; 95% confidence interval, CI: 1.27-3.85) and to acute lymphoblastic leukemia (ALL) (OR=1.77; 95% CI: 1.06-2.95) with no sufficient evidence of excess risk for other leukemias (OR=1.34; 95% CI: 0.38-4.69). Following IVF, OR for ALL was 2.58 (95% CI: 1.37-4.84) before age 3.8 and 4.29 (95% CI: 1.49-12.37) before age 2 years. Conclusions: IVF seems to be associated with increased risk of early onset ALL in the offspring.

KW - Acute lymphoblastic leukemia

KW - Assisted reproductive technologies

KW - Childhood cancer

KW - Risk factor

UR - http://www.scopus.com/inward/record.url?scp=84855818606&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855818606&partnerID=8YFLogxK

U2 - 10.1002/pbc.23194

DO - 10.1002/pbc.23194

M3 - Article

C2 - 21618418

AN - SCOPUS:84855818606

VL - 58

SP - 930

EP - 936

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

SN - 1545-5009

IS - 6

ER -