In vitro evaluation of CP-62,993, erythromycin, clindamycin, and tetracycline against Chlamydia trachomatis

M. Walsh, E. W. Kappus, T. C. Quinn

Research output: Contribution to journalArticlepeer-review

Abstract

The antimicrobial activity of CP-62,993 against four Chlamydia trachomatis isolates was compared with those of erythromycin, clindamycin, and tetracycline. The MIC of CP-62,993 was 0.26 to 1.02 μg/ml for 100% inclusion inhibition and 0.031 to 0.063 μg/ml for 50% inclusion inhibition. With pharmacokinetic and antimicrobial studies demonstrating prolonged half-life and in vitro effectiveness, CP-62,993 may make possible a single, short-course treatment regimen for C. trachomatis infection.

Original languageEnglish (US)
Pages (from-to)811-812
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume31
Issue number5
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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