TY - JOUR
T1 - In vitro evaluation of CP-62,993, erythromycin, clindamycin, and tetracycline against Chlamydia trachomatis
AU - Walsh, M.
AU - Kappus, E. W.
AU - Quinn, T. C.
PY - 1987
Y1 - 1987
N2 - The antimicrobial activity of CP-62,993 against four Chlamydia trachomatis isolates was compared with those of erythromycin, clindamycin, and tetracycline. The MIC of CP-62,993 was 0.26 to 1.02 μg/ml for 100% inclusion inhibition and 0.031 to 0.063 μg/ml for 50% inclusion inhibition. With pharmacokinetic and antimicrobial studies demonstrating prolonged half-life and in vitro effectiveness, CP-62,993 may make possible a single, short-course treatment regimen for C. trachomatis infection.
AB - The antimicrobial activity of CP-62,993 against four Chlamydia trachomatis isolates was compared with those of erythromycin, clindamycin, and tetracycline. The MIC of CP-62,993 was 0.26 to 1.02 μg/ml for 100% inclusion inhibition and 0.031 to 0.063 μg/ml for 50% inclusion inhibition. With pharmacokinetic and antimicrobial studies demonstrating prolonged half-life and in vitro effectiveness, CP-62,993 may make possible a single, short-course treatment regimen for C. trachomatis infection.
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U2 - 10.1128/AAC.31.5.811
DO - 10.1128/AAC.31.5.811
M3 - Article
C2 - 3038010
AN - SCOPUS:0023254967
SN - 0066-4804
VL - 31
SP - 811
EP - 812
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 5
ER -