The antimicrobial activity of CP-62,993 against four Chlamydia trachomatis isolates was compared with those of erythromycin, clindamycin, and tetracycline. The MIC of CP-62,993 was 0.26 to 1.02 μg/ml for 100% inclusion inhibition and 0.031 to 0.063 μg/ml for 50% inclusion inhibition. With pharmacokinetic and antimicrobial studies demonstrating prolonged half-life and in vitro effectiveness, CP-62,993 may make possible a single, short-course treatment regimen for C. trachomatis infection.
|Original language||English (US)|
|Number of pages||2|
|Journal||Antimicrobial Agents and Chemotherapy|
|Publication status||Published - 1987|
ASJC Scopus subject areas
- Pharmacology (medical)