In-vitro effect of a diabetic serum factor on the generation of superoxide free radical, it's quenching ability and lysosomal degranulation in normal polymorpho nuclear leucocytes

S. Biswas, A. Bhelwa, A. Ittoop, S. Biswal, N. Nath

Research output: Contribution to journalArticle

Abstract

Normal polymorpho nuclear leucocytes (PMNL) when assaulted with diabetic serum factor in-vitro, recorded enhanced generation of oxygen free radical, and lysosomal degranulation. It also caused a decrease in the cytosolic superoxide dismutase activity. Time-plot studies revealed PMNL susceptibility to diabetic serum factor for oxidative injury and concomitant decrease in SOD, consequential for lysosomal degranulation.

Original languageEnglish (US)
Pages (from-to)75-78
Number of pages4
JournalIndian Journal of Clinical Biochemistry
Volume9
Issue number2
DOIs
StatePublished - Dec 1 1994
Externally publishedYes

Keywords

  • DSF
  • O. SOD
  • PMNL
  • lysosomal degranulation

ASJC Scopus subject areas

  • Clinical Biochemistry

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