In Vitro echinocandin susceptibility of Aspergillus isolates from patients enrolled in the transplant-associated infection surveillance network

Shawn R. Lockhart, Alicia J. Zimbeck, John W. Baddley, Kieren A. Marr, David R. Andes, Thomas J. Walsh, Carol A. Kauffman, Dimitrios P. Kontoyiannis, James I. Ito, Peter G. Pappas, Tom Chiller

Research output: Contribution to journalArticle

Abstract

We determined the echinocandin minimum effective concentration (MEC) values for caspofungin, micafungin, and anidulafungin against 288 Aspergillus isolates prospectively collected from transplant patients with proven or probable invasive aspergillosis between 2001 and 2006 as part of the Transplant- Associated Infection Surveillance Network (TRANSNET). We demonstrated that the vast majority of Aspergillus isolates had MEC values at or below the epidemiological cutoff values for caspofungin, micafungin, and anidulafungin, including those from patients who had received caspofungin.

Original languageEnglish (US)
Pages (from-to)3944-3946
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume55
Issue number8
DOIs
StatePublished - Aug 2011

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Lockhart, S. R., Zimbeck, A. J., Baddley, J. W., Marr, K. A., Andes, D. R., Walsh, T. J., Kauffman, C. A., Kontoyiannis, D. P., Ito, J. I., Pappas, P. G., & Chiller, T. (2011). In Vitro echinocandin susceptibility of Aspergillus isolates from patients enrolled in the transplant-associated infection surveillance network. Antimicrobial agents and chemotherapy, 55(8), 3944-3946. https://doi.org/10.1128/AAC.00428-11