In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important molds

Aspasia Katragkou; Matthew McCarthy; Joseph Meletiadis; Vidmantas Petraitis; Patriss W. Moradi; Gittel E. Strauss; Monique M. Fouant; Laura L. Kovanda; Ruta Petraitiene; Emmanuel Roilides; Thomas J. Walsh

doi:10.1128/AAC.03261-14

In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important molds

Aspasia Katragkou, Matthew McCarthy, Joseph Meletiadis, Vidmantas Petraitis, Patriss W. Moradi, Gittel E. Strauss, Monique M. Fouant, Laura L. Kovanda, Ruta Petraitiene, Emmanuel Roilides, Thomas J. Walsh

School of Medicine

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Whether isavuconazole, an extended-spectrum triazole, possesses synergistic activity in combination therapy with echinocandins or amphotericin B for the treatment of invasive molds infections has not been studied. Our in vitro combination studies showed that isavuconazole and micafungin are synergistically active against Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, and Cunninghamella bertholletiae. These results suggest that isavuconazole, in combination with micafungin, may have a role in the treatment of invasive aspergillosis and warrants further investigation.

Original language	English (US)
Pages (from-to)	6934-6937
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	58
Issue number	11
DOIs	https://doi.org/10.1128/AAC.03261-14
State	Published - Nov 1 2014

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Katragkou, A., McCarthy, M., Meletiadis, J., Petraitis, V., Moradi, P. W., Strauss, G. E., Fouant, M. M., Kovanda, L. L., Petraitiene, R., Roilides, E., & Walsh, T. J. (2014). In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important molds. Antimicrobial agents and chemotherapy, 58(11), 6934-6937. https://doi.org/10.1128/AAC.03261-14

Katragkou, A, McCarthy, M, Meletiadis, J, Petraitis, V, Moradi, PW, Strauss, GE, Fouant, MM, Kovanda, LL, Petraitiene, R, Roilides, E & Walsh, TJ 2014, 'In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important molds', Antimicrobial agents and chemotherapy, vol. 58, no. 11, pp. 6934-6937. https://doi.org/10.1128/AAC.03261-14

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abstract = "Whether isavuconazole, an extended-spectrum triazole, possesses synergistic activity in combination therapy with echinocandins or amphotericin B for the treatment of invasive molds infections has not been studied. Our in vitro combination studies showed that isavuconazole and micafungin are synergistically active against Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, and Cunninghamella bertholletiae. These results suggest that isavuconazole, in combination with micafungin, may have a role in the treatment of invasive aspergillosis and warrants further investigation.",

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AU - Katragkou, Aspasia

AU - McCarthy, Matthew

AU - Meletiadis, Joseph

AU - Petraitis, Vidmantas

AU - Moradi, Patriss W.

AU - Strauss, Gittel E.

AU - Fouant, Monique M.

AU - Kovanda, Laura L.

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AU - Roilides, Emmanuel

AU - Walsh, Thomas J.

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In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important molds

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