In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important molds

Aspasia Katragkou, Matthew McCarthy, Joseph Meletiadis, Vidmantas Petraitis, Patriss W. Moradi, Gittel E. Strauss, Monique M. Fouant, Laura L. Kovanda, Ruta Petraitiene, Emmanuel Roilides, Thomas J. Walsh

Research output: Contribution to journalArticle

Abstract

Whether isavuconazole, an extended-spectrum triazole, possesses synergistic activity in combination therapy with echinocandins or amphotericin B for the treatment of invasive molds infections has not been studied. Our in vitro combination studies showed that isavuconazole and micafungin are synergistically active against Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, and Cunninghamella bertholletiae. These results suggest that isavuconazole, in combination with micafungin, may have a role in the treatment of invasive aspergillosis and warrants further investigation.

Original languageEnglish (US)
Pages (from-to)6934-6937
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume58
Issue number11
DOIs
StatePublished - Nov 1 2014

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Katragkou, A., McCarthy, M., Meletiadis, J., Petraitis, V., Moradi, P. W., Strauss, G. E., Fouant, M. M., Kovanda, L. L., Petraitiene, R., Roilides, E., & Walsh, T. J. (2014). In vitro combination of isavuconazole with micafungin or amphotericin B deoxycholate against medically important molds. Antimicrobial agents and chemotherapy, 58(11), 6934-6937. https://doi.org/10.1128/AAC.03261-14