In vitro antituberculosis activities of the constituents isolated from Haloxylon salicornicum

Nazia Bibi, Sheraz Ahmad K. Tanoli, Sadia Farheen, Nighat Afza, Salman Siddiqi, Ying Zhang, Shahana U. Kazmi, Abdul Malik

Research output: Contribution to journalArticle

Abstract

In vitro antituberculosis activities of fractions and pure compounds (1-20) including seven triterpenes, two alkaloids, two cycloheximide derivatives, two coumarins six sterol derivatives and a long chain alcohol, respectively, isolated from Haloxylon salicornicum were determined against Mycobecterium tuberculosis H37Rv. Actively growing cultures were tested by rapid colorimetric method while the stationary phase cultures were tested by drug exposure methods for bactericidal activity. The MIC values were found to be 50 μg/ml for compounds 15, 19 and 20 where as rest of the compounds invariably showed MIC value of 100 μg/ml against the logarithmic phase culture. These were compare to Isoniazid as a control drug. The compounds exhibited no activity against the stationary phase culture of M. tuberculosis H37Rv up to 200 μg/ml. Further studies are required to investigate the in vivo efficacies and activities of the compounds in combination with antimicrobials that are already being used for TB therapy.

Original languageEnglish (US)
Pages (from-to)4173-4176
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number14
DOIs
StatePublished - Jul 15 2010

Keywords

  • Antituberculosis activities
  • Haloxylon salicornicum
  • Isoniazid
  • Mycobecterium tuberculosis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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