In vitro antimicrobial susceptibility of bacterial enteropathogens isolated from international travelers to Mexico, Guatemala, and India from 2006 to 2008

Jeannette Ouyang-Latimer, Syed Jafri, Audrey VanTassel, Zhi Dong Jiang, Kaur Gurleen, Savio Rodriguez, Ranjan K. Nandy, Thandavaryan Ramamurthy, Santanu Chatterjee, Robin McKenzie, Robert Steffen, Herbert L. DuPont

Research output: Contribution to journalArticle

Abstract

The incidence rates of travelers' diarrhea (TD) have remained high for the last 50 years. More recently, there have been increasing recommendations for self-initiated therapy and use of prophylactic drugs for TD. We last examined the in vitro susceptibilities of commonly used antibiotics against TD pathogens in 1997. We now examine 456 enteropathogens isolated from adult travelers to Mexico, India, and Guatemala with diarrhea acquired between 2006 and 2008 to determine changes in susceptibility against 10 different antimicrobials by the agar dilution method. Traditional antibiotics, such as ampicillin, trimethoprim-sulfamethoxazole, and doxycycline, continue to show high levels of resistance. Current first-line antibiotic agents, including fluoroquinolones and azithromycin, showed significantly higher MICs than in our earlier study, and MIC 90 levels were above the Clinical and Laboratory Standards Institute cutoffs for resistance. There were significant geographical differences in resistance patterns when Central America was compared with India. Entertoxigenic Escherichia coli (ETEC) isolates showed increased resistance to ciprofloxacin (P = 0.023) and levofloxacin (P = 0.0078) in India compared with Central America. Enteroaggregative E. coli (EAEC) isolates from Central America showed increased resistance to nearly all of the antibiotics tested. Compared to MICs of isolates 10 years prior, there were 4- to 10-fold increases in MIC 90 values for ceftriaxone, ciprofloxacin, levofloxacin, and azithromycin for both ETEC and EAEC. There were no significant changes in rifaximin MICs. Rising MICs over time imply the need for continuous surveillance of susceptibility patterns worldwide and geographically specific recommendations in TD therapy.

Original languageEnglish (US)
Pages (from-to)874-878
Number of pages5
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number2
DOIs
StatePublished - Feb 2011

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Guatemala
Mexico
India
Diarrhea
Central America
Escherichia coli
Anti-Bacterial Agents
Levofloxacin
Azithromycin
Ciprofloxacin
rifaximin
Ceftriaxone
Doxycycline
Fluoroquinolones
Sulfamethoxazole Drug Combination Trimethoprim
Ampicillin
Agar
In Vitro Techniques
Incidence
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

In vitro antimicrobial susceptibility of bacterial enteropathogens isolated from international travelers to Mexico, Guatemala, and India from 2006 to 2008. / Ouyang-Latimer, Jeannette; Jafri, Syed; VanTassel, Audrey; Jiang, Zhi Dong; Gurleen, Kaur; Rodriguez, Savio; Nandy, Ranjan K.; Ramamurthy, Thandavaryan; Chatterjee, Santanu; McKenzie, Robin; Steffen, Robert; DuPont, Herbert L.

In: Antimicrobial Agents and Chemotherapy, Vol. 55, No. 2, 02.2011, p. 874-878.

Research output: Contribution to journalArticle

Ouyang-Latimer, J, Jafri, S, VanTassel, A, Jiang, ZD, Gurleen, K, Rodriguez, S, Nandy, RK, Ramamurthy, T, Chatterjee, S, McKenzie, R, Steffen, R & DuPont, HL 2011, 'In vitro antimicrobial susceptibility of bacterial enteropathogens isolated from international travelers to Mexico, Guatemala, and India from 2006 to 2008', Antimicrobial Agents and Chemotherapy, vol. 55, no. 2, pp. 874-878. https://doi.org/10.1128/AAC.00739-10
Ouyang-Latimer, Jeannette ; Jafri, Syed ; VanTassel, Audrey ; Jiang, Zhi Dong ; Gurleen, Kaur ; Rodriguez, Savio ; Nandy, Ranjan K. ; Ramamurthy, Thandavaryan ; Chatterjee, Santanu ; McKenzie, Robin ; Steffen, Robert ; DuPont, Herbert L. / In vitro antimicrobial susceptibility of bacterial enteropathogens isolated from international travelers to Mexico, Guatemala, and India from 2006 to 2008. In: Antimicrobial Agents and Chemotherapy. 2011 ; Vol. 55, No. 2. pp. 874-878.
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