In vitro and in vivo antimycobacterial activity of antiinflammatory drug, diclofenac sodium

N. K. Dutta, K. Asok Kumar, Kaushiki Mazumdar, Sujata G. Dastidar, R. Ray, A. N. Chakrabarty

Research output: Contribution to journalArticlepeer-review

Abstract

The non-steroidal antiinflammatory drug diclofenac sodium exhibited remarkable inhibitory action against both drug sensitive and drug resistant clinical isolates of Mycobacterium tuberculosis, as well as other mycobacteria. This agent was tested in vitro against 45 different strains of mycobacteria, most of which were inhibited by the drug at 10-25 μg/ml concentration. When tested in vivo, diclofenac, injected at 10 mg/kg body weight of a Swiss strain of white mice, could significantly protect them when challenged with a 50 median lethal dose of M. tuberculosis H37 Rv102. According to Chisquare test, the in vivo data were highly significant (P<0.01).

Original languageEnglish (US)
Pages (from-to)922-927
Number of pages6
JournalIndian journal of experimental biology
Volume42
Issue number9
StatePublished - Sep 1 2004
Externally publishedYes

Keywords

  • Antiinflammatory drug
  • Antimycobacterial activity
  • Diclofenac sodium

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology

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