In vitro and in vivo antimycobacterial activity of an antihypertensive agent methyl-L-DOPA

Noton Kumar Dutta, Kaushiki Mazumdar, Sujata G. Dastidar, A. N. Chakrabarty, Yoshiaki Shirataki, Noboru Motohashi

Research output: Contribution to journalArticlepeer-review

Abstract

Methyl-L-DOPA, an antihypertensive agent, has significant in vitro activity against a variety of atypical mycobacteria such as the Mycobacterium avium complex, M. scrofulaceum, M. xenopi and M. marinum, and rare pathogens like M. fortuitum. In the present investigation, the screening of the in vitro activity was further extended by testing the in vitro activity against a total of 53 different strains of mycobacteria, including 34 clinical isolates of both drug-sensitive and drug-resistant Mycobacterium tuberculosis. Most of the strains were inhibited at 10-25 μg/mL concentrations of the drug. When methyl-L-DOPA was injected into male mice at a concentration of 10 μg/g body weight (20 g each), methyl-L-DOPA significantly protected them when challenged with a 50 median lethal dose of M. tuberculosis H37Rv102. According to the χ2 test, the in vivo data were highly significant (p<0.01).

Original languageEnglish (US)
Pages (from-to)539-546
Number of pages8
JournalIn Vivo
Volume19
Issue number3
StatePublished - 2005
Externally publishedYes

Keywords

  • Antihypertensive agent
  • Antimycobacterial activity
  • Methyl-L-DOPA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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