TY - JOUR
T1 - In Vitro Activation
T2 - A Possible New Frontier for Treatment of Primary Ovarian Insufficiency
AU - Cordeiro, Christina N.
AU - Christianson, Mindy S.
AU - Selter, Jessica H.
AU - Segars, James H.
N1 - Publisher Copyright:
© The Author(s) 2015.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - In vitro activation (IVA) represents a new frontier in the treatment of women with primary ovarian insufficiency as well as patients with cancer desiring fertility preservation. Here, we review the biological basis of IVA and the recent translation of IVA to humans by targeting Hippo and Akt-signaling pathways. We then provide a new integrated viewpoint on IVA, highlighting basic science research on the aspects of follicular development and ovarian tissue transplantation which may potentially optimize future translational research on IVA. Specific topics discussed include cryopreservation techniques, additional IVA pathway targets, the roles of actin polymerization, paracrine and endocrine factors, and the role of mechanical signaling and associated tissue rigidity in controlling ovarian follicular activation. Further research and improved understanding is needed to optimize success of IVA.
AB - In vitro activation (IVA) represents a new frontier in the treatment of women with primary ovarian insufficiency as well as patients with cancer desiring fertility preservation. Here, we review the biological basis of IVA and the recent translation of IVA to humans by targeting Hippo and Akt-signaling pathways. We then provide a new integrated viewpoint on IVA, highlighting basic science research on the aspects of follicular development and ovarian tissue transplantation which may potentially optimize future translational research on IVA. Specific topics discussed include cryopreservation techniques, additional IVA pathway targets, the roles of actin polymerization, paracrine and endocrine factors, and the role of mechanical signaling and associated tissue rigidity in controlling ovarian follicular activation. Further research and improved understanding is needed to optimize success of IVA.
KW - Akt stimulation
KW - fertility preservation
KW - in vitro activation
KW - mechanical signaling
KW - primary ovarian insufficiency
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U2 - 10.1177/1933719115625842
DO - 10.1177/1933719115625842
M3 - Article
C2 - 26787101
AN - SCOPUS:84961246494
SN - 1933-7191
VL - 23
SP - 429
EP - 438
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 4
ER -