TY - JOUR
T1 - In utero effects of chemicals on reproductive tissues in females
AU - Miller, Kimberly P.
AU - Borgeest, Christina
AU - Greenfeld, Chuck
AU - Tomic, Dragana
AU - Flaws, Jodi A.
PY - 2004/7/15
Y1 - 2004/7/15
N2 - Chemicals found in the environment as industrial byproducts or pollutants as well as those that are prescribed or part of our daily lives can have multiple effects on the human body. The manner in which we are exposed, and the levels we are exposed to are significant contributing factors. Adults have the bodily defense mechanisms in place to combat exposures to adverse toxicants and general pollution at a variety of levels. However, developing organisms may not have adequate defense mechanisms, and toxicants can have a significant effect on their health and development. In this review, we take particular note of the toxicities of chemicals on the developing female reproductive system as a result of in utero exposure. Environmental and prescribed chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), diethylstilbestrol, and genistein, as well as others, will be reviewed for their in utero toxicity in the neuroendocrine system, the ovary, oviduct, placenta, uterus, vagina, cervix, and mammary gland.
AB - Chemicals found in the environment as industrial byproducts or pollutants as well as those that are prescribed or part of our daily lives can have multiple effects on the human body. The manner in which we are exposed, and the levels we are exposed to are significant contributing factors. Adults have the bodily defense mechanisms in place to combat exposures to adverse toxicants and general pollution at a variety of levels. However, developing organisms may not have adequate defense mechanisms, and toxicants can have a significant effect on their health and development. In this review, we take particular note of the toxicities of chemicals on the developing female reproductive system as a result of in utero exposure. Environmental and prescribed chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), diethylstilbestrol, and genistein, as well as others, will be reviewed for their in utero toxicity in the neuroendocrine system, the ovary, oviduct, placenta, uterus, vagina, cervix, and mammary gland.
KW - Environmental chemicals
KW - in utero
KW - Reproductive tissues
UR - http://www.scopus.com/inward/record.url?scp=3242678020&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3242678020&partnerID=8YFLogxK
U2 - 10.1016/j.taap.2003.07.016
DO - 10.1016/j.taap.2003.07.016
M3 - Article
C2 - 15236949
AN - SCOPUS:3242678020
SN - 0041-008X
VL - 198
SP - 111
EP - 131
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
IS - 2
ER -