In Swedish families with hereditary prostate cancer, linkage to the HPC1 locus on chromosome 1q24-25 is restricted to families with early-onset prostate cancer

Henrik Grönberg, Jeffrey Smith, Monika Emanuelsson, Björn Anders Jonsson, Anders Bergh, John Carpten, William B Isaacs, Jianfeng Xu, Deborah Meyers, Jeffrey Trent, Jan Erik Damber

Research output: Contribution to journalArticle

Abstract

Prostate cancer clusters in some families, and an estimated 5%-10% of all cases are estimated to result from inheritance of prostate cancer- susceptibility genes. We previously reported evidence of linkage to the 1q24- 25 region (HPC1) in 91 North American and Swedish families each with multiple cases of prostate cancer (Smith et al. 1996). In the present report we analyze 40 (12 original and 28 newly identified) Swedish families with hereditary prostate cancer (HPC) that, on the basis of 40 markers spanning a 25-cM interval within 1q24-25, have evidence of linkage. In the complete set of families, a maximum two-point LOD score of 1.10 was observed at D1S413 (at a recombination fraction [θ] of .1), with a maximum NPL (nonparametric linkage) Z score of 1.64 at D1S202 (P = .05). The evidence of linkage to this region originated almost exclusively from the subset of 12 early-onset (age

Original languageEnglish (US)
Pages (from-to)134-140
Number of pages7
JournalAmerican Journal of Human Genetics
Volume65
Issue number1
DOIs
StatePublished - 1999

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Prostatic Neoplasms
Chromosomes
Neoplasm Genes
Age of Onset
Genetic Recombination
Familial Prostate cancer
sorbitan monopalmitate

ASJC Scopus subject areas

  • Genetics

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In Swedish families with hereditary prostate cancer, linkage to the HPC1 locus on chromosome 1q24-25 is restricted to families with early-onset prostate cancer. / Grönberg, Henrik; Smith, Jeffrey; Emanuelsson, Monika; Jonsson, Björn Anders; Bergh, Anders; Carpten, John; Isaacs, William B; Xu, Jianfeng; Meyers, Deborah; Trent, Jeffrey; Damber, Jan Erik.

In: American Journal of Human Genetics, Vol. 65, No. 1, 1999, p. 134-140.

Research output: Contribution to journalArticle

Grönberg, Henrik ; Smith, Jeffrey ; Emanuelsson, Monika ; Jonsson, Björn Anders ; Bergh, Anders ; Carpten, John ; Isaacs, William B ; Xu, Jianfeng ; Meyers, Deborah ; Trent, Jeffrey ; Damber, Jan Erik. / In Swedish families with hereditary prostate cancer, linkage to the HPC1 locus on chromosome 1q24-25 is restricted to families with early-onset prostate cancer. In: American Journal of Human Genetics. 1999 ; Vol. 65, No. 1. pp. 134-140.
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AU - Smith, Jeffrey

AU - Emanuelsson, Monika

AU - Jonsson, Björn Anders

AU - Bergh, Anders

AU - Carpten, John

AU - Isaacs, William B

AU - Xu, Jianfeng

AU - Meyers, Deborah

AU - Trent, Jeffrey

AU - Damber, Jan Erik

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