In situ cartilage and bone tissue engineering using phosphoester-containing hydrogels

Dong An Wang, Christopher G. Williams, Syuk Jin Lee, Jason D. Meyers, Anya Taboas, Nicholas Cher, Blanka Sharma, Tae Kyun Kim, Richard G S Spencer, Jennifer Hartt Elisseeff

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Tissue engineering techniques have developed a minimally invasive strategy to place hydrogel into a defect by macromer injection. Goat mesenchymal stem cells (gMSC) were introduced into a biodegradable phosphoester hydrogel and transplanted into the cartilage defect for 3-dimensional in vitro cultivation until the substitute begins to integrate with the surrounding tissue. Liquid precursor and rapid solidification provided the feasibility for implant-defect steric appropriateness, as well as cell encapsulation. It was concluded that the development of the hydrogel-cartilage transplantation system will be real-timely and non-invasively monitored through nuclear magnetic resonance imaging (MRI).

Original languageEnglish (US)
Title of host publicationMaterials Research Society Symposium Proceedings
EditorsJ.Y. Wong, A.L. Plant, C.E. Schmidt, L. Shea, A.J. Coury, C.S. Chen, A.E. Barron, H.-A. Klok, T.J. Deming
Pages165-167
Number of pages3
VolumeEXS
Edition1
Publication statusPublished - 2004
Event2003 MRS Fall Meeting - Boston, MA, United States
Duration: Dec 1 2003Dec 4 2003

Other

Other2003 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period12/1/0312/4/03

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ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials

Cite this

Wang, D. A., Williams, C. G., Lee, S. J., Meyers, J. D., Taboas, A., Cher, N., ... Elisseeff, J. H. (2004). In situ cartilage and bone tissue engineering using phosphoester-containing hydrogels. In J. Y. Wong, A. L. Plant, C. E. Schmidt, L. Shea, A. J. Coury, C. S. Chen, A. E. Barron, H-A. Klok, ... T. J. Deming (Eds.), Materials Research Society Symposium Proceedings (1 ed., Vol. EXS, pp. 165-167). [F8.14]