In Search of the Holy Grail for Drosophila TRP

Craig Montell

doi:10.1016/j.neuron.2008.06.006

In Search of the Holy Grail for Drosophila TRP

Craig Montell

School of Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Activation of the archetypal Transient Receptor Potential (TRP) channel, which is essential for Drosophila phototransduction, depends on a phospholipase C (PLC). However, the precise mechanism linking PLC to the gating of TRP has been elusive. In this issue of Neuron, Leung et al. provide compelling evidence that a diacylglycerol (DAG) lipase (INAE), acting downstream of the PLC, is essential for opening TRP. These results strongly support the model that a DAG metabolite is critical for TRP activation and suggest that mammalian DAG lipases may play similar roles.

Original language	English (US)
Pages (from-to)	825-827
Number of pages	3
Journal	Neuron
Volume	58
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2008.06.006
State	Published - Jun 26 2008

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neuron.2008.06.006

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abstract = "Activation of the archetypal Transient Receptor Potential (TRP) channel, which is essential for Drosophila phototransduction, depends on a phospholipase C (PLC). However, the precise mechanism linking PLC to the gating of TRP has been elusive. In this issue of Neuron, Leung et al. provide compelling evidence that a diacylglycerol (DAG) lipase (INAE), acting downstream of the PLC, is essential for opening TRP. These results strongly support the model that a DAG metabolite is critical for TRP activation and suggest that mammalian DAG lipases may play similar roles.",

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In Search of the Holy Grail for Drosophila TRP

Abstract

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