In Search of the Holy Grail for Drosophila TRP

Craig Montell

Research output: Contribution to journalArticlepeer-review


Activation of the archetypal Transient Receptor Potential (TRP) channel, which is essential for Drosophila phototransduction, depends on a phospholipase C (PLC). However, the precise mechanism linking PLC to the gating of TRP has been elusive. In this issue of Neuron, Leung et al. provide compelling evidence that a diacylglycerol (DAG) lipase (INAE), acting downstream of the PLC, is essential for opening TRP. These results strongly support the model that a DAG metabolite is critical for TRP activation and suggest that mammalian DAG lipases may play similar roles.

Original languageEnglish (US)
Pages (from-to)825-827
Number of pages3
Issue number6
StatePublished - Jun 26 2008

ASJC Scopus subject areas

  • Neuroscience(all)


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