In Search of the Holy Grail for Drosophila TRP

Craig Montell

Research output: Contribution to journalArticle

Abstract

Activation of the archetypal Transient Receptor Potential (TRP) channel, which is essential for Drosophila phototransduction, depends on a phospholipase C (PLC). However, the precise mechanism linking PLC to the gating of TRP has been elusive. In this issue of Neuron, Leung et al. provide compelling evidence that a diacylglycerol (DAG) lipase (INAE), acting downstream of the PLC, is essential for opening TRP. These results strongly support the model that a DAG metabolite is critical for TRP activation and suggest that mammalian DAG lipases may play similar roles.

Original languageEnglish (US)
Pages (from-to)825-827
Number of pages3
JournalNeuron
Volume58
Issue number6
DOIs
StatePublished - Jun 26 2008

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Type C Phospholipases
Drosophila
Lipoprotein Lipase
Light Signal Transduction
Transient Receptor Potential Channels
Diglycerides
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

In Search of the Holy Grail for Drosophila TRP. / Montell, Craig.

In: Neuron, Vol. 58, No. 6, 26.06.2008, p. 825-827.

Research output: Contribution to journalArticle

Montell, Craig. / In Search of the Holy Grail for Drosophila TRP. In: Neuron. 2008 ; Vol. 58, No. 6. pp. 825-827.
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