In hypertrophic cardiomyopathy reduction of relative resting myocardial blood flow is related to late enhancement, T2-signal and LV wall thickness

Katja Hueper, Antonia Zapf, Jan Skrok, Aurelio Pinheiro, Thomas A. Goldstein, Jie Zheng, Stefan Zimmerman, Ihab R Kamel, Roselle Abraham, Frank Wacker, David A. Bluemke, Theodore Abraham, Jens Vogel-Claussen

Research output: Contribution to journalArticle

Abstract

Objectives: To quantify resting myocardial blood flow (MBF) in the left ventricular (LV) wall of HCM patients and to determine the relationship to important parameters of disease: LV wall thickness, late gadolinium enhancement (LGE), T2-signal abnormalities (dark and bright signal), LV outflow tract obstruction and age. Materials and Methods: Seventy patients with proven HCM underwent cardiac MRI. Absolute and relative resting MBF were calculated from cardiac perfusion MRI by using the Fermi function model. The relationship between relative MBF and LV wall thickness, T2-signal abnormalities (T2 dark and T2 bright signal), LGE, age and LV outflow gradient as determined by echocardiography was determined using simple and multiple linear regression analysis. Categories of reduced and elevated perfusion in relation to non- or mildly affected reference segments were defined, and T2-signal characteristics and extent as well as pattern of LGE were examined. Statistical testing included linear and logistic regression analysis, unpaired t-test, odds ratios, and Fisher's exact test. Results: 804 segments in 70 patients were included in the analysis. In a simple linear regression model LV wall thickness (p

Original languageEnglish (US)
Article numbere41974
JournalPLoS One
Volume7
Issue number7
DOIs
StatePublished - Jul 30 2012

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gadolinium
Hypertrophic Cardiomyopathy
cardiomyopathy
Gadolinium
blood flow
Linear Models
Blood
Linear regression
Regression analysis
Magnetic resonance imaging
regression analysis
Echocardiography
Perfusion
echocardiography
Regression Analysis
Ventricular Outflow Obstruction
odds ratio
Logistics
testing
Logistic Models

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

In hypertrophic cardiomyopathy reduction of relative resting myocardial blood flow is related to late enhancement, T2-signal and LV wall thickness. / Hueper, Katja; Zapf, Antonia; Skrok, Jan; Pinheiro, Aurelio; Goldstein, Thomas A.; Zheng, Jie; Zimmerman, Stefan; Kamel, Ihab R; Abraham, Roselle; Wacker, Frank; Bluemke, David A.; Abraham, Theodore; Vogel-Claussen, Jens.

In: PLoS One, Vol. 7, No. 7, e41974, 30.07.2012.

Research output: Contribution to journalArticle

Hueper, K, Zapf, A, Skrok, J, Pinheiro, A, Goldstein, TA, Zheng, J, Zimmerman, S, Kamel, IR, Abraham, R, Wacker, F, Bluemke, DA, Abraham, T & Vogel-Claussen, J 2012, 'In hypertrophic cardiomyopathy reduction of relative resting myocardial blood flow is related to late enhancement, T2-signal and LV wall thickness', PLoS One, vol. 7, no. 7, e41974. https://doi.org/10.1371/journal.pone.0041974
Hueper, Katja ; Zapf, Antonia ; Skrok, Jan ; Pinheiro, Aurelio ; Goldstein, Thomas A. ; Zheng, Jie ; Zimmerman, Stefan ; Kamel, Ihab R ; Abraham, Roselle ; Wacker, Frank ; Bluemke, David A. ; Abraham, Theodore ; Vogel-Claussen, Jens. / In hypertrophic cardiomyopathy reduction of relative resting myocardial blood flow is related to late enhancement, T2-signal and LV wall thickness. In: PLoS One. 2012 ; Vol. 7, No. 7.
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