In development - new paradigm for understanding vascular disease

Research output: Contribution to journalReview articlepeer-review

Abstract

Under physiological conditions, the arterial endothelium exerts a powerful protective influence to maintain vascular homeostasis. However, during the development of vascular disease, these protective activities are lost, and dysfunctional endothelial cells actually promote disease pathogenesis. Numerous investigations have analyzed the characteristics of dysfunctional endothelium with a view to understanding the processes responsible for the dysfunction and to determining their role in vascular pathology. This review adopts an alternate approach: reviewing the mechanisms that contribute to the initial formation of a healthy protective endothelium and on how those mechanisms may be disrupted, precipitating the appearance of dysfunctional endothelial cells and the progression of vascular disease. This approach, which highlights the role of endothelial adherens junctions and vascular endothelial-cadherin in endothelial maturation and endothelial dysfunction, provides new insight into the remarkable biology of this important cell layer and its role in vascular protection and vascular disease.

Original languageEnglish (US)
Pages (from-to)148-263
Number of pages116
JournalJournal of cardiovascular pharmacology
Volume69
Issue number5
DOIs
StatePublished - May 1 2017

Keywords

  • VE-cadherin
  • adherens junctions
  • aging
  • atherosclerosis
  • developmental originals of vascular disease
  • endothelial dysfunction
  • postnatal development

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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