Improving the resolving power in a miniature MALDI TOP mass spectrometer

Robert D. English, Robert J. Cotter

Research output: Contribution to conferencePaperpeer-review

Abstract

Mass correlated acceleration (MCA) was combined with a shorter time-of-flight (TOF) analyzer in a MALDI TOF mass spectrometer to assess the performance of MCA in a miniature instrument. Instrumental parameters such as TOF dimensions and delay time settings were optimized to achieve optimum ion focusing. Mass spectra were collected using a custom MALDI instrument with a pulsed nitrogen laser. The results show that compared to pulsed extraction (PE), MCA supplied better focusing across a wider mass range for a protein tryptic digestion and a peptide mixture.

Original languageEnglish (US)
Pages863-864
Number of pages2
StatePublished - Dec 1 2002
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

ASJC Scopus subject areas

  • Spectroscopy

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