Improving the CAC Score by Addition of Regional Measures of Calcium Distribution. Multi-Ethnic Study of Atherosclerosis

Michael Blaha, Matthew J. Budoff, Rajesh Tota-Maharaj, Zeina A. Dardari, Nathan D. Wong, Richard A. Kronmal, John Eng, Wendy S Post, Roger S Blumenthal, Khurram Nasir

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of this study was to investigate whether inclusion of simple measures of calcified plaque distribution might improve the ability of the traditional Agatston coronary artery calcium (CAC) score to predict cardiovascular events. Background: Agatston CAC scoring does not include information on the location and distributional pattern of detectable calcified plaque. Methods: We studied 3,262 (50%) individuals with baseline CAC >0 from the Multi-Ethnic Study of Atherosclerosis. Multivessel CAC was defined by the number of coronary vessels with CAC (scored 1 to 4, including the left main). The "diffusivity index" was calculated as 1 - (CAC in most affected vessel/total CAC), and was used to group participants into concentrated and diffuse CAC patterns. Multivariable Cox proportional hazards regression, area under the curve, and net reclassification improvement analyses were performed for both coronary heart disease (CHD) and cardiovascular disease (CVD) events to assess whether measures of regional CAC distribution add to the traditional Agatston CAC score. Results: Mean age of the population was 66 ± 10 years, with 42% women. Median follow-up was 10.0 (9.5 to 10.7) years and there were 368 CHD and 493 CVD events during follow-up. Considerable heterogeneity existed between CAC score group and number of vessels with CAC (p <0.01). Addition of number of vessels with CAC significantly improved capacity to predict CHD and CVD events in survival analysis (hazard ratio: 1.9 to 3.5 for 4-vessel vs. 1-vessel CAC), area under the curve analysis (C-statistic improvement of 0.01 to 0.033), and net reclassification improvement analysis (category-less net reclassification improvement 0.10 to 0.45). Although a diffuse CAC pattern was associated with worse outcomes in participants with ≥2 vessels with CAC (hazard ratio: 1.33 to 1.41; p <0.05), adding this variable to the Agatston CAC score and number of vessels with CAC did not further improve global risk prediction. Conclusions: The number of coronary arteries with calcified plaque, indicating increasingly "diffuse" multivessel subclinical atherosclerosis, adds significantly to the traditional Agatston CAC score for the prediction of CHD and CVD events.

Original languageEnglish (US)
JournalJACC: Cardiovascular Imaging
DOIs
StateAccepted/In press - Nov 13 2015

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Atherosclerosis
Coronary Vessels
Calcium
Coronary Disease
Cardiovascular Diseases
Area Under Curve
Survival Analysis

Keywords

  • Cardiac computed tomography
  • Risk prediction
  • Risk stratification

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Improving the CAC Score by Addition of Regional Measures of Calcium Distribution. Multi-Ethnic Study of Atherosclerosis. / Blaha, Michael; Budoff, Matthew J.; Tota-Maharaj, Rajesh; Dardari, Zeina A.; Wong, Nathan D.; Kronmal, Richard A.; Eng, John; Post, Wendy S; Blumenthal, Roger S; Nasir, Khurram.

In: JACC: Cardiovascular Imaging, 13.11.2015.

Research output: Contribution to journalArticle

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abstract = "Objectives: The aim of this study was to investigate whether inclusion of simple measures of calcified plaque distribution might improve the ability of the traditional Agatston coronary artery calcium (CAC) score to predict cardiovascular events. Background: Agatston CAC scoring does not include information on the location and distributional pattern of detectable calcified plaque. Methods: We studied 3,262 (50{\%}) individuals with baseline CAC >0 from the Multi-Ethnic Study of Atherosclerosis. Multivessel CAC was defined by the number of coronary vessels with CAC (scored 1 to 4, including the left main). The {"}diffusivity index{"} was calculated as 1 - (CAC in most affected vessel/total CAC), and was used to group participants into concentrated and diffuse CAC patterns. Multivariable Cox proportional hazards regression, area under the curve, and net reclassification improvement analyses were performed for both coronary heart disease (CHD) and cardiovascular disease (CVD) events to assess whether measures of regional CAC distribution add to the traditional Agatston CAC score. Results: Mean age of the population was 66 ± 10 years, with 42{\%} women. Median follow-up was 10.0 (9.5 to 10.7) years and there were 368 CHD and 493 CVD events during follow-up. Considerable heterogeneity existed between CAC score group and number of vessels with CAC (p <0.01). Addition of number of vessels with CAC significantly improved capacity to predict CHD and CVD events in survival analysis (hazard ratio: 1.9 to 3.5 for 4-vessel vs. 1-vessel CAC), area under the curve analysis (C-statistic improvement of 0.01 to 0.033), and net reclassification improvement analysis (category-less net reclassification improvement 0.10 to 0.45). Although a diffuse CAC pattern was associated with worse outcomes in participants with ≥2 vessels with CAC (hazard ratio: 1.33 to 1.41; p <0.05), adding this variable to the Agatston CAC score and number of vessels with CAC did not further improve global risk prediction. Conclusions: The number of coronary arteries with calcified plaque, indicating increasingly {"}diffuse{"} multivessel subclinical atherosclerosis, adds significantly to the traditional Agatston CAC score for the prediction of CHD and CVD events.",
keywords = "Cardiac computed tomography, Risk prediction, Risk stratification",
author = "Michael Blaha and Budoff, {Matthew J.} and Rajesh Tota-Maharaj and Dardari, {Zeina A.} and Wong, {Nathan D.} and Kronmal, {Richard A.} and John Eng and Post, {Wendy S} and Blumenthal, {Roger S} and Khurram Nasir",
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T1 - Improving the CAC Score by Addition of Regional Measures of Calcium Distribution. Multi-Ethnic Study of Atherosclerosis

AU - Blaha, Michael

AU - Budoff, Matthew J.

AU - Tota-Maharaj, Rajesh

AU - Dardari, Zeina A.

AU - Wong, Nathan D.

AU - Kronmal, Richard A.

AU - Eng, John

AU - Post, Wendy S

AU - Blumenthal, Roger S

AU - Nasir, Khurram

PY - 2015/11/13

Y1 - 2015/11/13

N2 - Objectives: The aim of this study was to investigate whether inclusion of simple measures of calcified plaque distribution might improve the ability of the traditional Agatston coronary artery calcium (CAC) score to predict cardiovascular events. Background: Agatston CAC scoring does not include information on the location and distributional pattern of detectable calcified plaque. Methods: We studied 3,262 (50%) individuals with baseline CAC >0 from the Multi-Ethnic Study of Atherosclerosis. Multivessel CAC was defined by the number of coronary vessels with CAC (scored 1 to 4, including the left main). The "diffusivity index" was calculated as 1 - (CAC in most affected vessel/total CAC), and was used to group participants into concentrated and diffuse CAC patterns. Multivariable Cox proportional hazards regression, area under the curve, and net reclassification improvement analyses were performed for both coronary heart disease (CHD) and cardiovascular disease (CVD) events to assess whether measures of regional CAC distribution add to the traditional Agatston CAC score. Results: Mean age of the population was 66 ± 10 years, with 42% women. Median follow-up was 10.0 (9.5 to 10.7) years and there were 368 CHD and 493 CVD events during follow-up. Considerable heterogeneity existed between CAC score group and number of vessels with CAC (p <0.01). Addition of number of vessels with CAC significantly improved capacity to predict CHD and CVD events in survival analysis (hazard ratio: 1.9 to 3.5 for 4-vessel vs. 1-vessel CAC), area under the curve analysis (C-statistic improvement of 0.01 to 0.033), and net reclassification improvement analysis (category-less net reclassification improvement 0.10 to 0.45). Although a diffuse CAC pattern was associated with worse outcomes in participants with ≥2 vessels with CAC (hazard ratio: 1.33 to 1.41; p <0.05), adding this variable to the Agatston CAC score and number of vessels with CAC did not further improve global risk prediction. Conclusions: The number of coronary arteries with calcified plaque, indicating increasingly "diffuse" multivessel subclinical atherosclerosis, adds significantly to the traditional Agatston CAC score for the prediction of CHD and CVD events.

AB - Objectives: The aim of this study was to investigate whether inclusion of simple measures of calcified plaque distribution might improve the ability of the traditional Agatston coronary artery calcium (CAC) score to predict cardiovascular events. Background: Agatston CAC scoring does not include information on the location and distributional pattern of detectable calcified plaque. Methods: We studied 3,262 (50%) individuals with baseline CAC >0 from the Multi-Ethnic Study of Atherosclerosis. Multivessel CAC was defined by the number of coronary vessels with CAC (scored 1 to 4, including the left main). The "diffusivity index" was calculated as 1 - (CAC in most affected vessel/total CAC), and was used to group participants into concentrated and diffuse CAC patterns. Multivariable Cox proportional hazards regression, area under the curve, and net reclassification improvement analyses were performed for both coronary heart disease (CHD) and cardiovascular disease (CVD) events to assess whether measures of regional CAC distribution add to the traditional Agatston CAC score. Results: Mean age of the population was 66 ± 10 years, with 42% women. Median follow-up was 10.0 (9.5 to 10.7) years and there were 368 CHD and 493 CVD events during follow-up. Considerable heterogeneity existed between CAC score group and number of vessels with CAC (p <0.01). Addition of number of vessels with CAC significantly improved capacity to predict CHD and CVD events in survival analysis (hazard ratio: 1.9 to 3.5 for 4-vessel vs. 1-vessel CAC), area under the curve analysis (C-statistic improvement of 0.01 to 0.033), and net reclassification improvement analysis (category-less net reclassification improvement 0.10 to 0.45). Although a diffuse CAC pattern was associated with worse outcomes in participants with ≥2 vessels with CAC (hazard ratio: 1.33 to 1.41; p <0.05), adding this variable to the Agatston CAC score and number of vessels with CAC did not further improve global risk prediction. Conclusions: The number of coronary arteries with calcified plaque, indicating increasingly "diffuse" multivessel subclinical atherosclerosis, adds significantly to the traditional Agatston CAC score for the prediction of CHD and CVD events.

KW - Cardiac computed tomography

KW - Risk prediction

KW - Risk stratification

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