Improving risk assessment: Toxicological research needs

Mark Toraason, Mel Andersen, Matthew S. Bogdanffy, David Dankovic, Elaine Faustman, Paul Foster, Clay Frederick, Lynne Haber, Carole A. Kimmel, Steven Lewis, Roger McClellan, Ronald Melnick, Frank Mirer, Kevin Morgan, Val Schaeffer, Ellen Silbergeld, William Slikker, James Swenberg, Harri Vainio

Research output: Contribution to journalArticle

Abstract

A workshop convened to define research needs in toxicology identified several deficiencies in data and methods currently applied in risk assessment. The workshop panel noted that improving the link between chemical exposure and toxicological response requires a better understanding of the biological basis for inter- and intra-human variability and susceptibility. This understanding will not be complete unless all life stages are taken into consideration. Because animal studies serve as a foundation for toxicological assessment, proper accounting for cross-species extrapolation is essential. To achieve this, adjustments for dose-rate effects must be improved, which will aid in extrapolating toxicological responses to low doses and from short-term exposures. Success depends on greater use of validated biologically based doseresponse models that include pharmacokinetic and pharmacodynamic data. Research in these areas will help define uncertainty factors and reduce reliance on underlying default assumptions. Throughout the workshop the panel recognized that biomedical science and toxicology in particular is on the verge of a revolution because of advances in genomics and proteomics. Data from these high-output technologies are anticipated to greatly improve risk assessment by enabling scientists to better define and model the elements of the relationship between exposure to biological hazards and health risks in populations with differing susceptibilities.

Original languageEnglish (US)
Pages (from-to)1405-1419
Number of pages15
JournalHuman and Ecological Risk Assessment
Volume8
Issue number6
DOIs
StatePublished - Oct 2002
Externally publishedYes

Fingerprint

Risk assessment
Toxicology
risk assessment
toxicology
Pharmacodynamics
Pharmacokinetics
Health risks
Research
Extrapolation
Hazards
Animals
Education
proteomics
health risk
genomics
hazard
Genomics
animal
Proteomics
Uncertainty

Keywords

  • Dose response
  • Exposure assessment
  • Genomics
  • Life stages
  • Pharmacokinetics
  • Susceptibility

ASJC Scopus subject areas

  • Ecological Modeling
  • Management, Monitoring, Policy and Law

Cite this

Toraason, M., Andersen, M., Bogdanffy, M. S., Dankovic, D., Faustman, E., Foster, P., ... Vainio, H. (2002). Improving risk assessment: Toxicological research needs. Human and Ecological Risk Assessment, 8(6), 1405-1419. https://doi.org/10.1080/20028091057439

Improving risk assessment : Toxicological research needs. / Toraason, Mark; Andersen, Mel; Bogdanffy, Matthew S.; Dankovic, David; Faustman, Elaine; Foster, Paul; Frederick, Clay; Haber, Lynne; Kimmel, Carole A.; Lewis, Steven; McClellan, Roger; Melnick, Ronald; Mirer, Frank; Morgan, Kevin; Schaeffer, Val; Silbergeld, Ellen; Slikker, William; Swenberg, James; Vainio, Harri.

In: Human and Ecological Risk Assessment, Vol. 8, No. 6, 10.2002, p. 1405-1419.

Research output: Contribution to journalArticle

Toraason, M, Andersen, M, Bogdanffy, MS, Dankovic, D, Faustman, E, Foster, P, Frederick, C, Haber, L, Kimmel, CA, Lewis, S, McClellan, R, Melnick, R, Mirer, F, Morgan, K, Schaeffer, V, Silbergeld, E, Slikker, W, Swenberg, J & Vainio, H 2002, 'Improving risk assessment: Toxicological research needs', Human and Ecological Risk Assessment, vol. 8, no. 6, pp. 1405-1419. https://doi.org/10.1080/20028091057439
Toraason M, Andersen M, Bogdanffy MS, Dankovic D, Faustman E, Foster P et al. Improving risk assessment: Toxicological research needs. Human and Ecological Risk Assessment. 2002 Oct;8(6):1405-1419. https://doi.org/10.1080/20028091057439
Toraason, Mark ; Andersen, Mel ; Bogdanffy, Matthew S. ; Dankovic, David ; Faustman, Elaine ; Foster, Paul ; Frederick, Clay ; Haber, Lynne ; Kimmel, Carole A. ; Lewis, Steven ; McClellan, Roger ; Melnick, Ronald ; Mirer, Frank ; Morgan, Kevin ; Schaeffer, Val ; Silbergeld, Ellen ; Slikker, William ; Swenberg, James ; Vainio, Harri. / Improving risk assessment : Toxicological research needs. In: Human and Ecological Risk Assessment. 2002 ; Vol. 8, No. 6. pp. 1405-1419.
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