TY - JOUR
T1 - Improving recruitment in clinical trials
T2 - Why eligible participants decline
AU - Brintnall-Karabelas, Julie
AU - Sung, Susanna
AU - Cadman, Mary Ellen
AU - Squires, Carol
AU - Whorton, Katherine
AU - Pao, Maryland
PY - 2011/3
Y1 - 2011/3
N2 - There IS a need to explore why protocol-eligible subjects refuse participation in clinical trials. Without a clear understanding, participation by representative populations will be an ongoing obstacle to recruitment. This descriptive research study analyzes frequency data regarding a sample of 965 individuals who, despite being eligible for studies with the National Institute of Mental Health intramural program, declined research participation. Overall, responses regarding reasons for declining fell into the following five categories: a result of specific protocol issues; inconvenience; for other reasons not mentioned; financial reasons; and, lastly, decided to participate elsewhere. The results of this study identify common factors which suggest there are steps that investigators can take to better accommodate the needs of the public and, consequently, improve research participation.
AB - There IS a need to explore why protocol-eligible subjects refuse participation in clinical trials. Without a clear understanding, participation by representative populations will be an ongoing obstacle to recruitment. This descriptive research study analyzes frequency data regarding a sample of 965 individuals who, despite being eligible for studies with the National Institute of Mental Health intramural program, declined research participation. Overall, responses regarding reasons for declining fell into the following five categories: a result of specific protocol issues; inconvenience; for other reasons not mentioned; financial reasons; and, lastly, decided to participate elsewhere. The results of this study identify common factors which suggest there are steps that investigators can take to better accommodate the needs of the public and, consequently, improve research participation.
KW - Clinical trials
KW - Recruitment
KW - Refusal to participate
UR - http://www.scopus.com/inward/record.url?scp=79954481278&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79954481278&partnerID=8YFLogxK
U2 - 10.1525/jer.2011.6.1.69
DO - 10.1525/jer.2011.6.1.69
M3 - Article
C2 - 21460590
AN - SCOPUS:79954481278
SN - 1556-2646
VL - 6
SP - 69
EP - 74
JO - Journal of Empirical Research on Human Research Ethics
JF - Journal of Empirical Research on Human Research Ethics
IS - 1
ER -