Improving pain management and long-term outcomes following high-energy orthopaedic trauma (pain study)

Renan C. Castillo, Srinivasa N. Raja, Katherine P. Frey, Heather A. Vallier, Paul Tornetta, Todd Jaeblon, Brandon J. Goff, Allan Gottschalk, Daniel O. Scharfstein, Robert V. O'Toole, Lauren E. Allen, Anthony R. Carlini, Gregory De Lissovoy, Ellen J. MacKenzie, Tara J. Taylor, Yingjie Weng

Research output: Contribution to journalArticle

Abstract

Poor pain control after orthopaedic trauma is a predictor of physical disability and numerous negative long-term outcomes. Despite increased awareness of the negative consequences of poorly controlled pain, analgesic therapy among hospitalized patients after orthopaedic trauma remains inconsistent and often inadequate. The Pain study is a 3 armed, prospective, double-blind, multicenter randomized trial designed to evaluate the effect of standard pain management versus standard pain management plus perioperative nonsteroidal anti-inflammatory drugs or pregabalin in patients of ages 18-85 with extremity fractures. The primary outcomes are chronic pain, opioid utilization during the 48 hours after definitive fixation and surgery for nonunion in the year after fixation. Secondary outcomes include preoperative and postoperative pain intensity, adverse events and complications, physical function, depression, and post-traumatic stress disorder. One year treatment costs are also compared between the groups.

Original languageEnglish (US)
Pages (from-to)S71-S77
JournalJournal of Orthopaedic Trauma
Volume31
DOIs
StatePublished - 2017

Fingerprint

Pain Management
Orthopedics
Pain
Wounds and Injuries
Post-Traumatic Stress Disorders
Postoperative Pain
Chronic Pain
Health Care Costs
Opioid Analgesics
Multicenter Studies
Analgesics
Anti-Inflammatory Agents
Extremities
Depression
Pharmaceutical Preparations
Therapeutics

Keywords

  • Nonunion
  • Opioids
  • Pain management
  • Randomized trial

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Improving pain management and long-term outcomes following high-energy orthopaedic trauma (pain study). / Castillo, Renan C.; Raja, Srinivasa N.; Frey, Katherine P.; Vallier, Heather A.; Tornetta, Paul; Jaeblon, Todd; Goff, Brandon J.; Gottschalk, Allan; Scharfstein, Daniel O.; O'Toole, Robert V.; Allen, Lauren E.; Carlini, Anthony R.; De Lissovoy, Gregory; MacKenzie, Ellen J.; Taylor, Tara J.; Weng, Yingjie.

In: Journal of Orthopaedic Trauma, Vol. 31, 2017, p. S71-S77.

Research output: Contribution to journalArticle

@article{0e3ec67d1c294df18abb51911175da8b,
title = "Improving pain management and long-term outcomes following high-energy orthopaedic trauma (pain study)",
abstract = "Poor pain control after orthopaedic trauma is a predictor of physical disability and numerous negative long-term outcomes. Despite increased awareness of the negative consequences of poorly controlled pain, analgesic therapy among hospitalized patients after orthopaedic trauma remains inconsistent and often inadequate. The Pain study is a 3 armed, prospective, double-blind, multicenter randomized trial designed to evaluate the effect of standard pain management versus standard pain management plus perioperative nonsteroidal anti-inflammatory drugs or pregabalin in patients of ages 18-85 with extremity fractures. The primary outcomes are chronic pain, opioid utilization during the 48 hours after definitive fixation and surgery for nonunion in the year after fixation. Secondary outcomes include preoperative and postoperative pain intensity, adverse events and complications, physical function, depression, and post-traumatic stress disorder. One year treatment costs are also compared between the groups.",
keywords = "Nonunion, Opioids, Pain management, Randomized trial",
author = "Castillo, {Renan C.} and Raja, {Srinivasa N.} and Frey, {Katherine P.} and Vallier, {Heather A.} and Paul Tornetta and Todd Jaeblon and Goff, {Brandon J.} and Allan Gottschalk and Scharfstein, {Daniel O.} and O'Toole, {Robert V.} and Allen, {Lauren E.} and Carlini, {Anthony R.} and {De Lissovoy}, Gregory and MacKenzie, {Ellen J.} and Taylor, {Tara J.} and Yingjie Weng",
year = "2017",
doi = "10.1097/BOT.0000000000000793",
language = "English (US)",
volume = "31",
pages = "S71--S77",
journal = "Journal of Orthopaedic Trauma",
issn = "0890-5339",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Improving pain management and long-term outcomes following high-energy orthopaedic trauma (pain study)

AU - Castillo, Renan C.

AU - Raja, Srinivasa N.

AU - Frey, Katherine P.

AU - Vallier, Heather A.

AU - Tornetta, Paul

AU - Jaeblon, Todd

AU - Goff, Brandon J.

AU - Gottschalk, Allan

AU - Scharfstein, Daniel O.

AU - O'Toole, Robert V.

AU - Allen, Lauren E.

AU - Carlini, Anthony R.

AU - De Lissovoy, Gregory

AU - MacKenzie, Ellen J.

AU - Taylor, Tara J.

AU - Weng, Yingjie

PY - 2017

Y1 - 2017

N2 - Poor pain control after orthopaedic trauma is a predictor of physical disability and numerous negative long-term outcomes. Despite increased awareness of the negative consequences of poorly controlled pain, analgesic therapy among hospitalized patients after orthopaedic trauma remains inconsistent and often inadequate. The Pain study is a 3 armed, prospective, double-blind, multicenter randomized trial designed to evaluate the effect of standard pain management versus standard pain management plus perioperative nonsteroidal anti-inflammatory drugs or pregabalin in patients of ages 18-85 with extremity fractures. The primary outcomes are chronic pain, opioid utilization during the 48 hours after definitive fixation and surgery for nonunion in the year after fixation. Secondary outcomes include preoperative and postoperative pain intensity, adverse events and complications, physical function, depression, and post-traumatic stress disorder. One year treatment costs are also compared between the groups.

AB - Poor pain control after orthopaedic trauma is a predictor of physical disability and numerous negative long-term outcomes. Despite increased awareness of the negative consequences of poorly controlled pain, analgesic therapy among hospitalized patients after orthopaedic trauma remains inconsistent and often inadequate. The Pain study is a 3 armed, prospective, double-blind, multicenter randomized trial designed to evaluate the effect of standard pain management versus standard pain management plus perioperative nonsteroidal anti-inflammatory drugs or pregabalin in patients of ages 18-85 with extremity fractures. The primary outcomes are chronic pain, opioid utilization during the 48 hours after definitive fixation and surgery for nonunion in the year after fixation. Secondary outcomes include preoperative and postoperative pain intensity, adverse events and complications, physical function, depression, and post-traumatic stress disorder. One year treatment costs are also compared between the groups.

KW - Nonunion

KW - Opioids

KW - Pain management

KW - Randomized trial

UR - http://www.scopus.com/inward/record.url?scp=85017320685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017320685&partnerID=8YFLogxK

U2 - 10.1097/BOT.0000000000000793

DO - 10.1097/BOT.0000000000000793

M3 - Article

C2 - 28323806

AN - SCOPUS:85017320685

VL - 31

SP - S71-S77

JO - Journal of Orthopaedic Trauma

JF - Journal of Orthopaedic Trauma

SN - 0890-5339

ER -