Improving medication adherence with two-way short message service reminders in sickle cell disease and asthma: A feasibility randomized controlled trial

Brandi M. Pernell, Michael R. DeBaun, Kathleen Becker, Mark Rodeghier, Valencia Bryant, Robert M. Cronin

Research output: Contribution to journalArticle

Abstract

Introduction: Sickle cell disease (SCD) is a childhood and adult disease that primarily affects African Americans, characterized by life threatening sequelae mitigated by medications. One-way and two-way short message service (SMS) medication reminders have differing efficacy in chronic diseases. There is limited literature about SMS medication reminders in SCD. Objective: The goal of this study was to test the feasibility, defined by recruitment/acceptance, retention/ attrition, and technology utilization, of two-way SMS medication reminders in individuals with SCD with and without asthma. Materials and Methods: Participants were randomly allocated to standard care or reminders. Two-way SMS reminders were automated using Research Electronic Data Capture (REDCap) for hydroxyurea, fluticasone, budesonide and montelukast. Adherence was measured using the Morisky Medication Adherence Scale-8 (MMAS-8). Asthma control was assessed using the Childhood and Adult-Asthma Control Tests (ACT). Participants were enrolled 28 to 60 days with a common termination date. Results: The recruitment rate was 95% (47/49) and 82.9% completed the study. Among the 47 study participants enrolled, 51.1% were male, 61.7% were adults, median age was 20 (range: 3 to 59), and 98% were African Americans. Of the 26 participants receiving messages, 20% responded on over 95% of the days and usage varied with an average response rate of 33%, ranging from 21% to 46%. Medication adherence scores improved significantly in the intervention group (3.42 before, 5.46 after; p=0.002), but not in the control group (3.90 before, 4.75 after; p=0.080). Childhood- ACT scores improved in the intervention group (19.20 before, 24.25 after). Adult-ACT scores within the intervention arm were unchanged (21.0 before, 22.0 after. ACT scores did not improve significantly. Conclusion: This study demonstrated the feasibility for two-way SMS medication reminders to improve medication adherence in a high-risk population where daily medication adherence is critical to health outcomes and quality of life.

Original languageEnglish (US)
Pages (from-to)541-559
Number of pages19
JournalApplied Clinical Informatics
Volume8
Issue number2
DOIs
Publication statusPublished - May 24 2017

    Fingerprint

Keywords

  • Asthma
  • Medication adherence
  • Short message service
  • Sickle cell anemia
  • Text

ASJC Scopus subject areas

  • Computer Science Applications
  • Health Informatics
  • Health Information Management

Cite this