Improving medication adherence in stroke patients through Short Text Messages (SMS4Stroke)-study protocol for a randomized, controlled trial

Ayeesha Kamran Kamal, Quratulain Nauman Shaikh, Omrana Pasha, Iqbal Azam, Muhammad Islam, Adeel Ali Memon, Hasan Rehman, Muhammad Affan, Sumaira Nazir, Salman Aziz, Muhammad Jan, Anita Andani, Abdul Muqeet, Bilal Ahmed, Shariq Khoja

Research output: Contribution to journalArticle

Abstract

Background: Stroke is a major cause of morbidity and mortality, especially in low and middle income countries. Medical management is the mainstay of therapy to prevent recurrence of stroke. Current estimates are that only 1 in 6 patients have perfect adherence to medication schedules. Using SMS (Short Messaging Service) as reminders to take medicines have been used previously for diseases such as diabetes and HIV with moderate success. We aim to explore the effectiveness and acceptability of SMS in increasing adherence to medications in patients with stroke. Methods: This will be a randomized, controlled, assessor blinded single center superiority trial. Adult participants with access to a cell phone and a history of stroke longer than 1month on multiple risk modifying medications will be selected from Neurology and Stroke Clinic. They will be randomized into two parallel groups in a 1:1 ratio via block technique with one group receiving the standard of care as per institutional guidelines while the parallel group receiving SMS reminders for each dose of medicine in addition to the standard of care. In addition intervention group will receive messages for lifestyle changes, medication information, risk factors and motivation for medication adherence. These will bemodeled on Social Cognitive Theory and Health Belief Model and will be categorized by Michies Taxonomy of Behavioral Change Communication. Patient compliance to medicines will be measured at baseline and then after 2months in each group by using the Morisky Medication Adherence Scale. The change in compliance to medication regimen after the intervention and the difference between the two groups will be used to determine the effectiveness of SMS reminders as a tool to increase medication compliance. The acceptability of the SMS will be determined by a tool designed for this study whose attributes are based Rogers Diffusion of innovation theory. A sample size of 86 participants in each arm will be sufficient to detect a difference of 1 point on the MMAS with a power of 90% and significance level of 5% between the two groups; using an attrition rate of 15%, 200 participants in all will be randomized. Discussion: The SMS for Stroke Study will provide evidence for feasibility and effectiveness of SMS in improving post stroke medication adherence in an LMIC setting. Trial registration:https://clinicaltrials.gov/ct2/show/NCT0198602311 /11/2013

Original languageEnglish (US)
Article number157
JournalBMC Neurology
Volume15
Issue number1
DOIs
StatePublished - Aug 28 2015
Externally publishedYes

Fingerprint

Text Messaging
Medication Adherence
Randomized Controlled Trials
Stroke
Standard of Care
Diffusion of Innovation
Cell Phones
Patient Compliance
Neurology
Sample Size
Life Style
Motivation
Appointments and Schedules
Communication
Medicine
HIV
Guidelines
Morbidity
Recurrence
Mortality

Keywords

  • Medication adherence
  • Prevention
  • SMS
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Improving medication adherence in stroke patients through Short Text Messages (SMS4Stroke)-study protocol for a randomized, controlled trial. / Kamal, Ayeesha Kamran; Shaikh, Quratulain Nauman; Pasha, Omrana; Azam, Iqbal; Islam, Muhammad; Memon, Adeel Ali; Rehman, Hasan; Affan, Muhammad; Nazir, Sumaira; Aziz, Salman; Jan, Muhammad; Andani, Anita; Muqeet, Abdul; Ahmed, Bilal; Khoja, Shariq.

In: BMC Neurology, Vol. 15, No. 1, 157, 28.08.2015.

Research output: Contribution to journalArticle

Kamal, AK, Shaikh, QN, Pasha, O, Azam, I, Islam, M, Memon, AA, Rehman, H, Affan, M, Nazir, S, Aziz, S, Jan, M, Andani, A, Muqeet, A, Ahmed, B & Khoja, S 2015, 'Improving medication adherence in stroke patients through Short Text Messages (SMS4Stroke)-study protocol for a randomized, controlled trial', BMC Neurology, vol. 15, no. 1, 157. https://doi.org/10.1186/s12883-015-0413-2
Kamal, Ayeesha Kamran ; Shaikh, Quratulain Nauman ; Pasha, Omrana ; Azam, Iqbal ; Islam, Muhammad ; Memon, Adeel Ali ; Rehman, Hasan ; Affan, Muhammad ; Nazir, Sumaira ; Aziz, Salman ; Jan, Muhammad ; Andani, Anita ; Muqeet, Abdul ; Ahmed, Bilal ; Khoja, Shariq. / Improving medication adherence in stroke patients through Short Text Messages (SMS4Stroke)-study protocol for a randomized, controlled trial. In: BMC Neurology. 2015 ; Vol. 15, No. 1.
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AU - Azam, Iqbal

AU - Islam, Muhammad

AU - Memon, Adeel Ali

AU - Rehman, Hasan

AU - Affan, Muhammad

AU - Nazir, Sumaira

AU - Aziz, Salman

AU - Jan, Muhammad

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AU - Muqeet, Abdul

AU - Ahmed, Bilal

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