Improving immunotherapy through glycodesign

Matthew J. Buettner, Sagar R. Shah, Christopher T. Saeui, Ryan Ariss, Kevin J. Yarema

Research output: Contribution to journalReview article

Abstract

Immunotherapy is revolutionizing health care, with the majority of high impact “drugs” approved in the past decade falling into this category of therapy. Despite considerable success, glycosylation-a key design parameter that ensures safety, optimizes biological response, and influences the pharmacokinetic properties of an immunotherapeutic-has slowed the development of this class of drugs in the past and remains challenging at present. This article describes how optimizing glycosylation through a variety of glycoengineering strategies provides enticing opportunities to not only avoid past pitfalls, but also to substantially improve immunotherapies including antibodies and recombinant proteins, and cell-based therapies. We cover design principles important for early stage pre-clinical development and also discuss how various glycoengineering strategies can augment the biomanufacturing process to ensure the overall effectiveness of immunotherapeutics.

Original languageEnglish (US)
Article number02485
JournalFrontiers in immunology
Volume9
Issue numberNOV
DOIs
StatePublished - Nov 2 2018

Keywords

  • Antibody-dependent cell cytotoxicity (ADCC)
  • Antibody-drug conjugates (ADCs)
  • Glycoengineering
  • Glycosylation
  • Immunotherapy
  • Metabolic glycoengineering
  • Monoclonal antibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Buettner, M. J., Shah, S. R., Saeui, C. T., Ariss, R., & Yarema, K. J. (2018). Improving immunotherapy through glycodesign. Frontiers in immunology, 9(NOV), [02485]. https://doi.org/10.3389/fimmu.2018.02485