Improvements in treatment success rates with directly observed therapy in Rio de Janeiro City

Elizabeth C C Soares, A. G F Pacheco, F. C Q Mello, B. Durovni, Richard E Chaisson, S. C. Cavalcante

Research output: Contribution to journalArticle

Abstract

SETTING: Rio de Janeiro City, Brazil. OBJECTIVE: To evaluate the effect of directly observed therapy (DOT) on treatment success, by comparing the treatment success rates between patients treated under DOT with those who received self-administered therapy (SAT). DESIGN: A longitudinal study in a cohort of tuberculosis (TB) patients. Of 9929 new pulmonary TB cases, 1190 (12%) were treated under DOT and 8739 (88%) under SAT. All patients received a three-drug regimen consisting of rifampicin (RMP), isoniazid (INH) and pyrazinamide for 2 months followed by 4 months of RMP and INH. RESULTS: Patients under DOT were more likely to convert to sputum-negative at the end of the second month than those treated under SAT (86.3% vs. 61.9%, P <0.001). DOT alone was significantly associated with successful treatment (OR 1.6, 95% CI 1.37-1.86, P <0.001), even when controlled by sex, age and positive smear or culture at enrollment (OR 1.56, 95% CI 1.33-1.82, P <0.001). CONCLUSION: This pilot DOTS implementation phase showed that DOT is highly effective and feasible in a large urban centre of a developing country.

Original languageEnglish (US)
Pages (from-to)690-695
Number of pages6
JournalInternational Journal of Tuberculosis and Lung Disease
Volume10
Issue number6
StatePublished - Jun 2006

Fingerprint

Directly Observed Therapy
Rifampin
Therapeutics
Pyrazinamide
Isoniazid
Sputum
Pulmonary Tuberculosis
Developing Countries
Brazil
Longitudinal Studies
Tuberculosis
Pharmaceutical Preparations

Keywords

  • DOT
  • DOTS
  • Pulmonary tuberculosis
  • Supervised treatment

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Soares, E. C. C., Pacheco, A. G. F., Mello, F. C. Q., Durovni, B., Chaisson, R. E., & Cavalcante, S. C. (2006). Improvements in treatment success rates with directly observed therapy in Rio de Janeiro City. International Journal of Tuberculosis and Lung Disease, 10(6), 690-695.

Improvements in treatment success rates with directly observed therapy in Rio de Janeiro City. / Soares, Elizabeth C C; Pacheco, A. G F; Mello, F. C Q; Durovni, B.; Chaisson, Richard E; Cavalcante, S. C.

In: International Journal of Tuberculosis and Lung Disease, Vol. 10, No. 6, 06.2006, p. 690-695.

Research output: Contribution to journalArticle

Soares, Elizabeth C C ; Pacheco, A. G F ; Mello, F. C Q ; Durovni, B. ; Chaisson, Richard E ; Cavalcante, S. C. / Improvements in treatment success rates with directly observed therapy in Rio de Janeiro City. In: International Journal of Tuberculosis and Lung Disease. 2006 ; Vol. 10, No. 6. pp. 690-695.
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