Improvement of brain tissue oxygenation by inhalation of carbogen

M. Ashkanian, P. Borghammer, A. Gjedde, L. Østergaard, M. Vafaee

Research output: Contribution to journalArticle

Abstract

Hyperoxic therapy for cerebral ischemia is suspected to reduce cerebral blood flow (CBF), due to the vasoconstrictive effect of oxygen on cerebral arterioles. We hypothesized that vasodilation predominates when 5% CO2 is added to the inhaled oxygen (carbogen). Therefore, we used positron emission tomography (PET) to measure CBF and cerebral metabolic rate of oxygen (CMRO2) during inhalation of test gases (O2, CO2, carbogen and atmospheric air) in 10 healthy volunteers. Arterial blood gases were recorded during administration of each gas. The data were analyzed with volume-of-interest and voxel-based statistical methods. Inhalation of CO2 or carbogen significantly increased global CBF, whereas pure oxygen decreased global CBF. The CMRO2 generally remained unchanged, except in white matter during oxygen inhalation relative to condition of atmospheric air inhalation. The volume-of-interest results were confirmed by statistical cluster analysis. Oxygen and carbogen were equally potent in increasing oxygen saturation of arterial blood (SaO2). The present data demonstrate that inhalation of carbogen increases both CBF and SaO2 in healthy adults. In conclusion we speculate that carbogen inhalation is sufficient for optimal oxygenation of healthy brain tissue, whereas carbogen induces concomitant increases of CBF and SaO2.

Original languageEnglish (US)
Pages (from-to)932-938
Number of pages7
JournalNeuroscience
Volume156
Issue number4
DOIs
StatePublished - Oct 28 2008
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Inhalation
Oxygen
Brain
Gases
Air
Arterioles
carbogen
Brain Ischemia
Vasodilation
Positron-Emission Tomography
Cluster Analysis
Healthy Volunteers

Keywords

  • brain tissue oxygenation
  • carbogen
  • CBF
  • OEF
  • oxygen

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ashkanian, M., Borghammer, P., Gjedde, A., Østergaard, L., & Vafaee, M. (2008). Improvement of brain tissue oxygenation by inhalation of carbogen. Neuroscience, 156(4), 932-938. https://doi.org/10.1016/j.neuroscience.2008.08.016

Improvement of brain tissue oxygenation by inhalation of carbogen. / Ashkanian, M.; Borghammer, P.; Gjedde, A.; Østergaard, L.; Vafaee, M.

In: Neuroscience, Vol. 156, No. 4, 28.10.2008, p. 932-938.

Research output: Contribution to journalArticle

Ashkanian, M, Borghammer, P, Gjedde, A, Østergaard, L & Vafaee, M 2008, 'Improvement of brain tissue oxygenation by inhalation of carbogen', Neuroscience, vol. 156, no. 4, pp. 932-938. https://doi.org/10.1016/j.neuroscience.2008.08.016
Ashkanian M, Borghammer P, Gjedde A, Østergaard L, Vafaee M. Improvement of brain tissue oxygenation by inhalation of carbogen. Neuroscience. 2008 Oct 28;156(4):932-938. https://doi.org/10.1016/j.neuroscience.2008.08.016
Ashkanian, M. ; Borghammer, P. ; Gjedde, A. ; Østergaard, L. ; Vafaee, M. / Improvement of brain tissue oxygenation by inhalation of carbogen. In: Neuroscience. 2008 ; Vol. 156, No. 4. pp. 932-938.
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