Improvement in overall survival from extremity soft tissue sarcoma over twenty years

Andrew J. Jacobs, Ryan Michels, Joanna Stein, Adam S. Levin

Research output: Contribution to journalArticlepeer-review

Abstract

Several patient demographic factors, including marital status, have been demonstrated to have prognostic significance for survival in extremity soft tissue sarcoma (ESTS). A study population of 12,546 adult patients diagnosed with ESTS from 1991 to 2010 was identified from the SEER database, a large population-based registry, in order to determine whether overall survival had changed over this recent 20-year period. The study population was divided into three groups by year of diagnosis: 1991-1996, 1997-2003, and 2004-2010. We used the Kaplan-Meier method and Cox proportional hazards regression to assess survival differences between different demographic groups and prognostic clinical characteristics. Over the course of time, the 5-year overall survival rates have increased from 28% in the earliest time period to 62% in the latest (P<0.0001). On multivariate analysis, the mortality rate progressively declined from the 1991-1996 group (HR: 3.02, CI: 2.78-3.29) to the 1997-2003 group (HR: 2.21, CI: 2.06-2.37), with the 2004-2010 group having the best overall survival, despite increases in the proportion of patients with tumors greater than 5 cm in size (P<0.0001), and those presenting with metastasis (P<0.0001).

Original languageEnglish (US)
Article number279601
JournalSarcoma
Volume2015
DOIs
StatePublished - 2015

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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