Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorrhage in rats

Donald Seyfried, Yuxia Han, Dunyue Lu, Jieli Chen, Ali Bydon, Michael Chopp

Research output: Contribution to journalArticle

Abstract

Object. Atorvastatin, a β-hydroxy-β-methylglutaryl coenzyme A reductase inhibitor, improves neurological functional outcome, reduces cerebral cell loss, and promotes regional cellular plasticity when administered after intracerebral hemorrhage (ICH) in rats. Methods. Autologous blood was stereotactically injected into the right striatum in rats, and atorvastatin was administered orally beginning 24 hours after ICH and continued daily for 1 week. At a dose of 2 mg/kg, atorvastatin significantly reduced the severity of neurological deficit from 2 to 4 weeks after ICH. The area of cell loss in the ipsilateral striatum was also significantly reduced in these animals. Consistent with previous study data, higher doses of atorvastatin (8 mg/kg) did not improve functional outcome or reduce the extent of injury. Histochemical stains for markers of synaptogenesis, immature neurons, and neuronal migration revealed increased labeling in the region of hemorrhage in the atorvastatin-treated rats. Conclusions. Analysis of the data in this study indicates that atorvastatin improves neurological recovery after experimental ICH and may do so in part by increasing neuronal plasticity.

Original languageEnglish (US)
Pages (from-to)104-107
Number of pages4
JournalJournal of neurosurgery
Volume101
Issue number1
DOIs
StatePublished - Jul 2004
Externally publishedYes

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Keywords

  • Intracerebral hemorrhage
  • Rat
  • Statin
  • Stroke

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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