Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors

Ned Charlton Sacktor; Richard L. Skolasky; Robert H. Lyles; Doreen Esposito; Ola A. Selnes; Justin C. McArthur

doi:10.3109/13550280009006385

Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors

Ned Charlton Sacktor, Richard L. Skolasky, Robert H. Lyles, Doreen Esposito, Ola A. Selnes, Justin C. McArthur

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P = 0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < - 1.0) at baseline, 18 (78%) improved on the GP non-dominant hand test alter initiating HAART (P = 0.001). GP non-dominant hand performance improved longitudinally in HIV+ patients initiating HAART, while matched HIV+ controls not on HAART did not change (P = 0.045). Significant improvement in motor performance can occur after HAART in HIV+ patients with impairment.

Original language	English (US)
Pages (from-to)	84-88
Number of pages	5
Journal	Journal of neurovirology
Volume	6
Issue number	1
DOIs	https://doi.org/10.3109/13550280009006385
State	Published - 2000

Keywords

Grooved pegboard
HIV
Protease inhibitors

ASJC Scopus subject areas

Neurology
Clinical Neurology
Cellular and Molecular Neuroscience
Virology

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10.3109/13550280009006385

Cite this

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title = "Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors",

abstract = "A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P = 0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < - 1.0) at baseline, 18 (78%) improved on the GP non-dominant hand test alter initiating HAART (P = 0.001). GP non-dominant hand performance improved longitudinally in HIV+ patients initiating HAART, while matched HIV+ controls not on HAART did not change (P = 0.045). Significant improvement in motor performance can occur after HAART in HIV+ patients with impairment.",

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AU - Lyles, Robert H.

AU - Esposito, Doreen

AU - Selnes, Ola A.

AU - McArthur, Justin C.

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Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors

Abstract

Keywords

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