Improvement in alertness and behavior in children treated with combination topiramate and vagus nerve stimulation

Eric H. Kossoff, Paula L. Pyzik

Research output: Contribution to journalArticlepeer-review

Abstract

It has been reported that vagus nerve stimulation (VNS) improves behavior in children, whereas topiramate has a less clear effect. Three boys, aged 5-12 years, with generalized slow spike-wave discharges and refractory epilepsy, were treated with combination therapy of topiramate and VNS. All three had a significant reduction in seizures, but even more dramatic improvement in aggression, social interaction, and ambulation. The Cyberonics Patient Outcome Registry was subsequently queried and a beneficial effect of this combination therapy on behavior (specifically alertness) beyond that of VNS and other anticonvulsants was noted. This did not appear to be due solely to seizure reduction, which was observed only differentially at 12 months.

Original languageEnglish (US)
Pages (from-to)256-259
Number of pages4
JournalEpilepsy and Behavior
Volume5
Issue number2
DOIs
StatePublished - Apr 2004

Keywords

  • Alertness
  • Behavior
  • Epilepsy
  • Topiramate
  • Vagus nerve stimulation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Behavioral Neuroscience

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