Improved tolerance of primary chemotherapy with reduced-dose carboplatin and paclitaxel in elderly ovarian cancer patients

Amanda Nickles Fader, Vivian von Gruenigen, Heidi Gibbons, Fadi Abushahin, David Starks, Maurie Markman, Jerome Belinson, Peter Rose

Research output: Contribution to journalArticle

Abstract

Objective: Elderly cancer patients are less likely to tolerate chemotherapy. We sought to compare the toxicity profiles and outcomes of elderly ovarian cancer patients treated with standard versus reduced-dose IV carboplatin/paclitaxel. Methods: A retrospective, multi-center analysis of women ≥ 70 years with papillary serous ovarian/primary peritoneal cancers diagnosed from 1994-2005 was performed. Reduced-dose (RD) patients received carboplatin AUC 4-5 and paclitaxel 135 mg/m2; standard-dose (SD) patients received carboplatin AUC 5-6 and paclitaxel 175 mg/m2. Patient variables collected included age, stage, performance status (PS), cytoreductive status, Charlson comorbidity scores, and growth factor administration. Results: One-hundred patients met the study criteria. RD patients (n = 26) were significantly older than SD patients (n = 74; median age 77.0 versus 74.7, respectively, p = 0.014). No differences were noted in stage, comorbidity scores, cytoreductive status or growth factor administration between cohorts. Incidence of grade 3-4 neutropenia was higher in the SD group (54.1% versus 19.2%; p = 0.002). SD patients were more likely to experience cumulative toxicity (p = 0.003) and required delays in therapy (p = 0.05). Although PS was poorer in SD patients (p = 0.02), on multivariate analysis, only the administration of the SD regimen predicted toxicity (p = 0.008). There were no differences in progression-free or overall survival between cohorts (median follow-up: 34 months). On multivariate analysis, age (p = 0.004) and PS (p = 0.008) had a significant impact on survival. Conclusion(s): This preliminary data suggests that reduced-dose carboplatin/paclitaxel may be better tolerated but equally effective as the standard regimen in elderly ovarian cancer patients. Age, performance status and other geriatric parameters should be considered when dosing chemotherapy in the elderly.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalGynecologic oncology
Volume109
Issue number1
DOIs
StatePublished - Apr 1 2008
Externally publishedYes

Keywords

  • Cancer in the elderly
  • Chemotherapy
  • Ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Improved tolerance of primary chemotherapy with reduced-dose carboplatin and paclitaxel in elderly ovarian cancer patients'. Together they form a unique fingerprint.

  • Cite this