Improved results of treatment in 30 cases of acute nonlymphocytic leukemia in childhood

S. Imashuku, S. Arakawa, S. Todo, Noriko Esumi, K. Tsunamoto, T. Hashida, Y. Morioka, S. Hibi, T. Nagai, F. Fujiwara

Research output: Contribution to journalArticle

Abstract

Thirty cases of childhood acute nonlymphocytic leukemia (ANLL) have been treated with intermittent, intensive multi-drug combinations during the past 5 years. Three patients never attained complete remission (CR) and 3 died of complications after less than one month of treatment. Twenty-four (86.7 %) attained CR with a median CCR of 26 months. The median for disease-free survival (DFS) among the total 30 cases was 15 months. Twelve out of the 24 CR patients have been disease-free for longer than 16 months, indicating significantly improved therapeutic results. Among the factors affecting prognosis, we found that patients with certain clonal abnormalities of leukemic cells and initial leukocytosis (greater than 40,000/microliter) had poor prognosis. Further revision of treatment should be considered for patients with high-risk ANLL.

Original languageEnglish (US)
Pages (from-to)2581-2587
Number of pages7
JournalJapanese Journal of Cancer and Chemotherapy
Volume13
Issue number8
StatePublished - Aug 1986
Externally publishedYes

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Acute Myeloid Leukemia
Leukocytosis
Drug Combinations
Therapeutics
Disease-Free Survival

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

Imashuku, S., Arakawa, S., Todo, S., Esumi, N., Tsunamoto, K., Hashida, T., ... Fujiwara, F. (1986). Improved results of treatment in 30 cases of acute nonlymphocytic leukemia in childhood. Japanese Journal of Cancer and Chemotherapy, 13(8), 2581-2587.

Improved results of treatment in 30 cases of acute nonlymphocytic leukemia in childhood. / Imashuku, S.; Arakawa, S.; Todo, S.; Esumi, Noriko; Tsunamoto, K.; Hashida, T.; Morioka, Y.; Hibi, S.; Nagai, T.; Fujiwara, F.

In: Japanese Journal of Cancer and Chemotherapy, Vol. 13, No. 8, 08.1986, p. 2581-2587.

Research output: Contribution to journalArticle

Imashuku, S, Arakawa, S, Todo, S, Esumi, N, Tsunamoto, K, Hashida, T, Morioka, Y, Hibi, S, Nagai, T & Fujiwara, F 1986, 'Improved results of treatment in 30 cases of acute nonlymphocytic leukemia in childhood', Japanese Journal of Cancer and Chemotherapy, vol. 13, no. 8, pp. 2581-2587.
Imashuku, S. ; Arakawa, S. ; Todo, S. ; Esumi, Noriko ; Tsunamoto, K. ; Hashida, T. ; Morioka, Y. ; Hibi, S. ; Nagai, T. ; Fujiwara, F. / Improved results of treatment in 30 cases of acute nonlymphocytic leukemia in childhood. In: Japanese Journal of Cancer and Chemotherapy. 1986 ; Vol. 13, No. 8. pp. 2581-2587.
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AU - Hashida, T.

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