Improved radioimaging and tumor localization with monoclonal F(ab')2

R. L. Wahl, C. W. Parker, G. W. Philpott

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Abstract

Monoclonal anti-tumor antibodies have great promise for radioimmunodetection and localization of tumors. Fab and F(ab')2 fragments, which lack the Fc fragment of antibody (Ab), are cleared more rapidly from the circulation and may have less nonspecific tissue binding than intact Ab. In radioimaging studies using a murine monoclonal antibody to carcinoembryonic antigen in a human colon carcinoma xenografted into hamsters, F(ab')2 fragments were shown superior to Fab fragments and intact antibody for scintiscanning. In double-label experiments with anti-CEA antibody and control monoclonal IgG, F(ab')2 fragments were found to give better and more rapid specific tumor localization than intact antibody or Fab fragments. F(ab')2 fragments offer significant promise for tumor imaging and possibly therapy.

Original languageEnglish (US)
Pages (from-to)316-325
Number of pages10
JournalJournal of Nuclear Medicine
Volume24
Issue number4
StatePublished - Dec 1 1983

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Wahl, R. L., Parker, C. W., & Philpott, G. W. (1983). Improved radioimaging and tumor localization with monoclonal F(ab')2. Journal of Nuclear Medicine, 24(4), 316-325.