Improved rabbit brain tumor model amenable to diagnostic radiographic procedures

B. S. Carson; J. H. Anderson; S. A. Grossman; J. Hilton; C. L. White; O. M. Colvin; A. W. Clark; L. B. Grochow; A. Kahn; K. J. Murray

doi:10.1227/00006123-198211000-00003

Improved rabbit brain tumor model amenable to diagnostic radiographic procedures

B. S. Carson, J. H. Anderson, S. A. Grossman, J. Hilton, C. L. White, O. M. Colvin, A. W. Clark, L. B. Grochow, A. Kahn, K. J. Murray

School of Medicine

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The VX2 carcinoma was used to create a rabbit brain tumor model. VX2 tumors were chemically dissociated and suspended in liquid medium. Twenty-five microlitres of the tumor suspension containing 3 x 10³, 3 x10⁴, or 3 x 10⁵ viable tumor cells were injected through cranial burr holes 6 mm into the right frontoparietal lobes of 17 rabbits. Fifteen of these developed histologically documented nodular intraparenchymal tumors. Tumors were demonstrable with cerebral computed tomographic scans and by cerebral angiography. The feasibility of surgical resection of lesions using the fluorescein staining technique was also demonstrated. This animal brain tumor model is suitable for neuro-oncology research focusing on imaging and therapeutic techniques.

Original language	English (US)
Pages (from-to)	603-608
Number of pages	6
Journal	Unknown Journal
Volume	11
Issue number	5
DOIs	https://doi.org/10.1227/00006123-198211000-00003
State	Published - 1982

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1227/00006123-198211000-00003

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title = "Improved rabbit brain tumor model amenable to diagnostic radiographic procedures",

abstract = "The VX2 carcinoma was used to create a rabbit brain tumor model. VX2 tumors were chemically dissociated and suspended in liquid medium. Twenty-five microlitres of the tumor suspension containing 3 x 103, 3 x104, or 3 x 105 viable tumor cells were injected through cranial burr holes 6 mm into the right frontoparietal lobes of 17 rabbits. Fifteen of these developed histologically documented nodular intraparenchymal tumors. Tumors were demonstrable with cerebral computed tomographic scans and by cerebral angiography. The feasibility of surgical resection of lesions using the fluorescein staining technique was also demonstrated. This animal brain tumor model is suitable for neuro-oncology research focusing on imaging and therapeutic techniques.",

author = "Carson, {B. S.} and Anderson, {J. H.} and Grossman, {S. A.} and J. Hilton and White, {C. L.} and Colvin, {O. M.} and Clark, {A. W.} and Grochow, {L. B.} and A. Kahn and Murray, {K. J.}",

year = "1982",

doi = "10.1227/00006123-198211000-00003",

language = "English (US)",

volume = "11",

pages = "603--608",

journal = "Unknown Journal",

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T1 - Improved rabbit brain tumor model amenable to diagnostic radiographic procedures

AU - Carson, B. S.

AU - Anderson, J. H.

AU - Grossman, S. A.

AU - Hilton, J.

AU - White, C. L.

AU - Colvin, O. M.

AU - Clark, A. W.

AU - Grochow, L. B.

AU - Kahn, A.

AU - Murray, K. J.

PY - 1982

Y1 - 1982

N2 - The VX2 carcinoma was used to create a rabbit brain tumor model. VX2 tumors were chemically dissociated and suspended in liquid medium. Twenty-five microlitres of the tumor suspension containing 3 x 103, 3 x104, or 3 x 105 viable tumor cells were injected through cranial burr holes 6 mm into the right frontoparietal lobes of 17 rabbits. Fifteen of these developed histologically documented nodular intraparenchymal tumors. Tumors were demonstrable with cerebral computed tomographic scans and by cerebral angiography. The feasibility of surgical resection of lesions using the fluorescein staining technique was also demonstrated. This animal brain tumor model is suitable for neuro-oncology research focusing on imaging and therapeutic techniques.

AB - The VX2 carcinoma was used to create a rabbit brain tumor model. VX2 tumors were chemically dissociated and suspended in liquid medium. Twenty-five microlitres of the tumor suspension containing 3 x 103, 3 x104, or 3 x 105 viable tumor cells were injected through cranial burr holes 6 mm into the right frontoparietal lobes of 17 rabbits. Fifteen of these developed histologically documented nodular intraparenchymal tumors. Tumors were demonstrable with cerebral computed tomographic scans and by cerebral angiography. The feasibility of surgical resection of lesions using the fluorescein staining technique was also demonstrated. This animal brain tumor model is suitable for neuro-oncology research focusing on imaging and therapeutic techniques.

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Improved rabbit brain tumor model amenable to diagnostic radiographic procedures

Abstract

ASJC Scopus subject areas

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