Improved quantification of chemical exchange saturation transfer (CEST) MRI using nonlocal means

Jing Yuan, Greta Seng Peng Mok, Qinwei Zhang, Yi Xiang Wang, Jinyuan Zhou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Chemical exchange saturation transfer (CEST) MRI offers a powerful molecular imaging tool by exploiting the proton exchanges between free water and labile exchangeable molecules in vivo. Accurate CEST quantification from Z-spectrum analysis, particularly at clinical field strengths, suffers from low contrast-to-noise ratio (CNR). In this study, we proposed the use of non-local means (NLM) for CEST-MRI denoising to improve the CEST contrast quantification. The experimental results showed that the NLM denoising effectively removed noise presented in the low signal-to-noise ratio (SNR) CEST images with high resolution and well preserved the tissue structures. The CEST contrast map generated from the NLM-denoised images was notably improved, which was closer to the map generated from images with 3.5-fold higher SNR and meanwhile had much less partial volume effect. NLM denoising holds great potentials for the clinical CEST-MRI quantification improvement without compromising spatial resolution.

Original languageEnglish (US)
Title of host publication2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479960972
DOIs
StatePublished - Mar 10 2016
EventIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014 - Seattle, United States
Duration: Nov 8 2014Nov 15 2014

Publication series

Name2014 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014

Other

OtherIEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2014
Country/TerritoryUnited States
CitySeattle
Period11/8/1411/15/14

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Fingerprint

Dive into the research topics of 'Improved quantification of chemical exchange saturation transfer (CEST) MRI using nonlocal means'. Together they form a unique fingerprint.

Cite this