TY - JOUR
T1 - Improved performance of enzyme-linked immunosorbent assays and the effect of human immunodeficiency virus coinfection on the serologic detection of herpes simplex virus type 2 in Rakai, Uganda
AU - Gamiel, Jordyn L.
AU - Tobian, Aaron A.R.
AU - Laeyendecker, Oliver B.
AU - Reynolds, Steven J.
AU - Morrow, Rhoda Ashley
AU - Serwadda, David
AU - Gray, Ronald H.
AU - Quinn, Thomas C.
PY - 2008/5
Y1 - 2008/5
N2 - Ugandan subjects (820) were tested by Focus HerpeSelect enzyme-linked immunosorbent assay (ELISA), Kalon herpes simplex virus type 2 ELISA, and BioKit rapid test, and the results were compared to those of Western blotting. Higher-than-standard-index cutoff values gave optimal sensitivity and specificity. Kalon ELISA was the optimal assay when an index value of 1.5 was used (sensitivity, 91.7%; specificity, 92.4%).
AB - Ugandan subjects (820) were tested by Focus HerpeSelect enzyme-linked immunosorbent assay (ELISA), Kalon herpes simplex virus type 2 ELISA, and BioKit rapid test, and the results were compared to those of Western blotting. Higher-than-standard-index cutoff values gave optimal sensitivity and specificity. Kalon ELISA was the optimal assay when an index value of 1.5 was used (sensitivity, 91.7%; specificity, 92.4%).
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U2 - 10.1128/CVI.00453-07
DO - 10.1128/CVI.00453-07
M3 - Article
C2 - 18321879
AN - SCOPUS:46249124886
SN - 1556-6811
VL - 15
SP - 888
EP - 890
JO - Clinical and Vaccine Immunology
JF - Clinical and Vaccine Immunology
IS - 5
ER -