Improved lipid profiles are associated with reduced incidence of coronary vascular events in asymptomatic patients with type 2 diabetes and impaired myocardial perfusion

Yoshimitsu Yamasaki, Naoto Katakami, Hideaki Kaneto, Kenichi Nakajima, Hideo Kusuoka, Atsunori Kashiwagi, Tsunehiko Nishimura

Research output: Contribution to journalArticle

Abstract

Aim: Individuals with type 2 diabetes are at high risk for cardiovascular events; however, a modality that could reduce risk has not been fully evaluated. We examined the annual incidence rate of cardiovascular events in asymptomatic Japanese diabetic patients who underwent gated myocardial perfusion single-photon computed tomography (SPECT). Methods: Asymptomatic patients (n=485) aged ≥50 years and with either a maximal carotid artery intima-media thickness of ≥ 1.1 mm, or urinary albumin ≥30 mg/g creatinine, or at least two of abdominal obesity, low HDL cholesterol, high triglyceride levels and hypertension were evaluated at 50 institutions using gated SPECT with the stress-rest protocol and were followed up for three years. In the patients with summed stress scores (SSS) of ≥9, the initial high cardiovascular incidence rate in the first year declined significantly (p

Original languageEnglish (US)
Pages (from-to)330-335
Number of pages6
JournalJournal of Atherosclerosis and Thrombosis
Volume20
Issue number4
DOIs
Publication statusPublished - 2013
Externally publishedYes

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Keywords

  • Tc-tetrofosmin
  • Cardiovascular events
  • Estimated glomerular filtration rate
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical

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