Improved diagnosis of pleural tuberculosis using the microscopic- observation drug-susceptibility technique

Marco Tovar; Mark J. Siedner; Robert H. Gilman; Carlos Santillan; Luz Caviedes; Teresa Valencia; Oswaldo Jave; A. Rod Escombe; David A.J. Moore; Carlton A. Evans

doi:10.1086/527447

Improved diagnosis of pleural tuberculosis using the microscopic- observation drug-susceptibility technique

Marco Tovar, Mark J. Siedner, Robert H. Gilman, Carlos Santillan, Luz Caviedes, Teresa Valencia, Oswaldo Jave, A. Rod Escombe, David A.J. Moore, Carlton A. Evans

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Tests for pleural tuberculosis are insensitive and expensive. We compared nonproprietary microscopic-observation drug-susceptibility (MODS) culture with Löwenstein-Jensen culture for evaluation of pleural specimens. MODS culture was associated with greatly increased diagnostic sensitivity and shorter time to diagnosis, compared with Löwenstein-Jensen culture (sensitivity of culture of biopsy specimens, 81% vs. 51%; time to diagnosis, 11 days vs. 24 days; P < .001). The MODS technique is inexpensive, allows drug-susceptibility testing, and is a considerably improved diagnostic method for pleural tuberculosis.

Original language	English (US)
Pages (from-to)	909-912
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	46
Issue number	6
DOIs	https://doi.org/10.1086/527447
State	Published - Mar 15 2008

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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Improved diagnosis of pleural tuberculosis using the microscopic- observation drug-susceptibility technique. / Tovar, Marco; Siedner, Mark J.; Gilman, Robert H.; Santillan, Carlos; Caviedes, Luz; Valencia, Teresa; Jave, Oswaldo; Escombe, A. Rod; Moore, David A.J.; Evans, Carlton A.

In: Clinical Infectious Diseases, Vol. 46, No. 6, 15.03.2008, p. 909-912.

Research output: Contribution to journal › Article › peer-review

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