Improved diagnosis of pleural tuberculosis using the microscopic- observation drug-susceptibility technique

Marco Tovar, Mark J. Siedner, Robert H. Gilman, Carlos Santillan, Luz Caviedes, Teresa Valencia, Oswaldo Jave, A. Rod Escombe, David A.J. Moore, Carlton A. Evans

Research output: Contribution to journalArticlepeer-review

Abstract

Tests for pleural tuberculosis are insensitive and expensive. We compared nonproprietary microscopic-observation drug-susceptibility (MODS) culture with Löwenstein-Jensen culture for evaluation of pleural specimens. MODS culture was associated with greatly increased diagnostic sensitivity and shorter time to diagnosis, compared with Löwenstein-Jensen culture (sensitivity of culture of biopsy specimens, 81% vs. 51%; time to diagnosis, 11 days vs. 24 days; P < .001). The MODS technique is inexpensive, allows drug-susceptibility testing, and is a considerably improved diagnostic method for pleural tuberculosis.

Original languageEnglish (US)
Pages (from-to)909-912
Number of pages4
JournalClinical Infectious Diseases
Volume46
Issue number6
DOIs
StatePublished - Mar 15 2008

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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