Improved Detection of Recurrent Hepatocellular Carcinomas in Arterial Phase With CAIPIRINHA-Dixon-TWIST-Volumetric Interpolated Breath-Hold Examination

Jinrong Qu, Shuai Han, Hongkai Zhang, Hui Liu, Zhaoqi Wang, Ihab R Kamel, Kiefer Berthold, Nickel Marcel Dominik, Shouning Zhang, Yafeng Dong, Lina Jiang, Cuicui Liu, Hailiang Li

Research output: Contribution to journalArticle

Abstract

PURPOSE: The aim of this study was to assess the detection rate of recurrent hepatocellular carcinoma (HCC) in arterial phase using multiarterial CAIPIRINHA-Dixon-TWIST-VIBE (MA-CDT-VIBE). MATERIALS AND METHODS: Fifty-eight patients with possible recurrence of HCC were retrospectively included in this cohort. Patients were scanned with a prototype dynamic contrast-enhanced breath-hold CDT-VIBE sequence, which included 6 arterial subphases with a temporal resolution of 2.64 seconds on a 3 T scanner. Absence and presence of recurrence was documented by consensus of 2 experienced radiologists using magnetic resonance imaging multiphase imaging and follow-up evaluation. The third of 6 arterial subphases was considered the equivalent-to-conventional single arterial phase from the contrast bolus timing perspective. The detection rate of recurrent HCCs in arterial phase by another 2 independent experienced readers was compared for all 6 arterial subphases of MA-CDT-VIBE and the equivalent-to-conventional single arterial phase. Interreader agreement was also calculated. RESULTS: Of the 55 patients reviewed, 46 patients (201 lesions) had recurrent HCC and 9 patients had no recurrence. There was an excellent interreader agreement for both MA-CDT-VIBE (κ = 1.000, P <0.0001) and the equivalent-to-conventional single arterial phase (κ = 0.850, P <0.0001). MA-CDT-VIBE showed the detection rate of 100% for all lesions with the diameter of less than 1 cm, 1 to 2 cm, and more than 2 cm. The equivalent-to-conventional single arterial phase resulted in the detection rate of 81.1% and 83.1% for all recurrent HCCs by the 2 readers, respectively, with 78.7% and 83.6% for lesions measuring less than 1 cm, 79.2% and 81.2% for lesions measuring 1 to 2 cm, and 89.7% and 87.2% for lesions measuring more than 2 cm. CONCLUSIONS: Compared with the equivalent-to-conventional single arterial phase, MA-CDT-VIBE with 6 arterial subphases demonstrated higher detection rate of recurrent HCCs in arterial phase and provided a wider arterial observation window, especially for recurrent HCCs less than 2 cm in diameter.

Original languageEnglish (US)
JournalInvestigative Radiology
DOIs
StateAccepted/In press - May 11 2016

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Hepatocellular Carcinoma
Recurrence
Magnetic Resonance Imaging
Observation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Improved Detection of Recurrent Hepatocellular Carcinomas in Arterial Phase With CAIPIRINHA-Dixon-TWIST-Volumetric Interpolated Breath-Hold Examination. / Qu, Jinrong; Han, Shuai; Zhang, Hongkai; Liu, Hui; Wang, Zhaoqi; Kamel, Ihab R; Berthold, Kiefer; Dominik, Nickel Marcel; Zhang, Shouning; Dong, Yafeng; Jiang, Lina; Liu, Cuicui; Li, Hailiang.

In: Investigative Radiology, 11.05.2016.

Research output: Contribution to journalArticle

Qu, Jinrong ; Han, Shuai ; Zhang, Hongkai ; Liu, Hui ; Wang, Zhaoqi ; Kamel, Ihab R ; Berthold, Kiefer ; Dominik, Nickel Marcel ; Zhang, Shouning ; Dong, Yafeng ; Jiang, Lina ; Liu, Cuicui ; Li, Hailiang. / Improved Detection of Recurrent Hepatocellular Carcinomas in Arterial Phase With CAIPIRINHA-Dixon-TWIST-Volumetric Interpolated Breath-Hold Examination. In: Investigative Radiology. 2016.
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abstract = "PURPOSE: The aim of this study was to assess the detection rate of recurrent hepatocellular carcinoma (HCC) in arterial phase using multiarterial CAIPIRINHA-Dixon-TWIST-VIBE (MA-CDT-VIBE). MATERIALS AND METHODS: Fifty-eight patients with possible recurrence of HCC were retrospectively included in this cohort. Patients were scanned with a prototype dynamic contrast-enhanced breath-hold CDT-VIBE sequence, which included 6 arterial subphases with a temporal resolution of 2.64 seconds on a 3 T scanner. Absence and presence of recurrence was documented by consensus of 2 experienced radiologists using magnetic resonance imaging multiphase imaging and follow-up evaluation. The third of 6 arterial subphases was considered the equivalent-to-conventional single arterial phase from the contrast bolus timing perspective. The detection rate of recurrent HCCs in arterial phase by another 2 independent experienced readers was compared for all 6 arterial subphases of MA-CDT-VIBE and the equivalent-to-conventional single arterial phase. Interreader agreement was also calculated. RESULTS: Of the 55 patients reviewed, 46 patients (201 lesions) had recurrent HCC and 9 patients had no recurrence. There was an excellent interreader agreement for both MA-CDT-VIBE (κ = 1.000, P <0.0001) and the equivalent-to-conventional single arterial phase (κ = 0.850, P <0.0001). MA-CDT-VIBE showed the detection rate of 100{\%} for all lesions with the diameter of less than 1 cm, 1 to 2 cm, and more than 2 cm. The equivalent-to-conventional single arterial phase resulted in the detection rate of 81.1{\%} and 83.1{\%} for all recurrent HCCs by the 2 readers, respectively, with 78.7{\%} and 83.6{\%} for lesions measuring less than 1 cm, 79.2{\%} and 81.2{\%} for lesions measuring 1 to 2 cm, and 89.7{\%} and 87.2{\%} for lesions measuring more than 2 cm. CONCLUSIONS: Compared with the equivalent-to-conventional single arterial phase, MA-CDT-VIBE with 6 arterial subphases demonstrated higher detection rate of recurrent HCCs in arterial phase and provided a wider arterial observation window, especially for recurrent HCCs less than 2 cm in diameter.",
author = "Jinrong Qu and Shuai Han and Hongkai Zhang and Hui Liu and Zhaoqi Wang and Kamel, {Ihab R} and Kiefer Berthold and Dominik, {Nickel Marcel} and Shouning Zhang and Yafeng Dong and Lina Jiang and Cuicui Liu and Hailiang Li",
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T1 - Improved Detection of Recurrent Hepatocellular Carcinomas in Arterial Phase With CAIPIRINHA-Dixon-TWIST-Volumetric Interpolated Breath-Hold Examination

AU - Qu, Jinrong

AU - Han, Shuai

AU - Zhang, Hongkai

AU - Liu, Hui

AU - Wang, Zhaoqi

AU - Kamel, Ihab R

AU - Berthold, Kiefer

AU - Dominik, Nickel Marcel

AU - Zhang, Shouning

AU - Dong, Yafeng

AU - Jiang, Lina

AU - Liu, Cuicui

AU - Li, Hailiang

PY - 2016/5/11

Y1 - 2016/5/11

N2 - PURPOSE: The aim of this study was to assess the detection rate of recurrent hepatocellular carcinoma (HCC) in arterial phase using multiarterial CAIPIRINHA-Dixon-TWIST-VIBE (MA-CDT-VIBE). MATERIALS AND METHODS: Fifty-eight patients with possible recurrence of HCC were retrospectively included in this cohort. Patients were scanned with a prototype dynamic contrast-enhanced breath-hold CDT-VIBE sequence, which included 6 arterial subphases with a temporal resolution of 2.64 seconds on a 3 T scanner. Absence and presence of recurrence was documented by consensus of 2 experienced radiologists using magnetic resonance imaging multiphase imaging and follow-up evaluation. The third of 6 arterial subphases was considered the equivalent-to-conventional single arterial phase from the contrast bolus timing perspective. The detection rate of recurrent HCCs in arterial phase by another 2 independent experienced readers was compared for all 6 arterial subphases of MA-CDT-VIBE and the equivalent-to-conventional single arterial phase. Interreader agreement was also calculated. RESULTS: Of the 55 patients reviewed, 46 patients (201 lesions) had recurrent HCC and 9 patients had no recurrence. There was an excellent interreader agreement for both MA-CDT-VIBE (κ = 1.000, P <0.0001) and the equivalent-to-conventional single arterial phase (κ = 0.850, P <0.0001). MA-CDT-VIBE showed the detection rate of 100% for all lesions with the diameter of less than 1 cm, 1 to 2 cm, and more than 2 cm. The equivalent-to-conventional single arterial phase resulted in the detection rate of 81.1% and 83.1% for all recurrent HCCs by the 2 readers, respectively, with 78.7% and 83.6% for lesions measuring less than 1 cm, 79.2% and 81.2% for lesions measuring 1 to 2 cm, and 89.7% and 87.2% for lesions measuring more than 2 cm. CONCLUSIONS: Compared with the equivalent-to-conventional single arterial phase, MA-CDT-VIBE with 6 arterial subphases demonstrated higher detection rate of recurrent HCCs in arterial phase and provided a wider arterial observation window, especially for recurrent HCCs less than 2 cm in diameter.

AB - PURPOSE: The aim of this study was to assess the detection rate of recurrent hepatocellular carcinoma (HCC) in arterial phase using multiarterial CAIPIRINHA-Dixon-TWIST-VIBE (MA-CDT-VIBE). MATERIALS AND METHODS: Fifty-eight patients with possible recurrence of HCC were retrospectively included in this cohort. Patients were scanned with a prototype dynamic contrast-enhanced breath-hold CDT-VIBE sequence, which included 6 arterial subphases with a temporal resolution of 2.64 seconds on a 3 T scanner. Absence and presence of recurrence was documented by consensus of 2 experienced radiologists using magnetic resonance imaging multiphase imaging and follow-up evaluation. The third of 6 arterial subphases was considered the equivalent-to-conventional single arterial phase from the contrast bolus timing perspective. The detection rate of recurrent HCCs in arterial phase by another 2 independent experienced readers was compared for all 6 arterial subphases of MA-CDT-VIBE and the equivalent-to-conventional single arterial phase. Interreader agreement was also calculated. RESULTS: Of the 55 patients reviewed, 46 patients (201 lesions) had recurrent HCC and 9 patients had no recurrence. There was an excellent interreader agreement for both MA-CDT-VIBE (κ = 1.000, P <0.0001) and the equivalent-to-conventional single arterial phase (κ = 0.850, P <0.0001). MA-CDT-VIBE showed the detection rate of 100% for all lesions with the diameter of less than 1 cm, 1 to 2 cm, and more than 2 cm. The equivalent-to-conventional single arterial phase resulted in the detection rate of 81.1% and 83.1% for all recurrent HCCs by the 2 readers, respectively, with 78.7% and 83.6% for lesions measuring less than 1 cm, 79.2% and 81.2% for lesions measuring 1 to 2 cm, and 89.7% and 87.2% for lesions measuring more than 2 cm. CONCLUSIONS: Compared with the equivalent-to-conventional single arterial phase, MA-CDT-VIBE with 6 arterial subphases demonstrated higher detection rate of recurrent HCCs in arterial phase and provided a wider arterial observation window, especially for recurrent HCCs less than 2 cm in diameter.

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