Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI

Varun Sethi, Tarek A. Yousry, Nils Muhlert, Maria Ron, Xavier Golay, Claudia Wheeler-Kingshott, David H. Miller, DeclanT Chard

Research output: Contribution to journalArticle

Abstract

Objective: Cortical grey matter lesions are common in multiple sclerosis (MS), but usually not seen on MRI. The authors compared the performance of double inversion recovery (DIR, currently considered the best available imaging sequence for detecting cortical lesions) with phase-sensitive inversion recovery (PSIR, a sequence allowing much higher resolution scans to be obtained in a clinically feasible time). Methods: Sixty MS patients and 30 healthy controls underwent MRI scanning on a 3 Tesla scanner. The authors compared intracortical (IC) and leucocortical (LC) lesion counts obtained with a standard DIR sequence (1X1X3 mm resolution, obtained in 4 min) and a PSIR sequence (0.5X0.5X2 mm, 11 min). Lesions were marked separately on DIR and PSIR scans. Results: In the whole MS cohort, more cortical lesions were seen on the higher-resolution PSIR than the DIR scans (IC mean±SD: 18.1±9.8 vs 5.9±4.5, p

Original languageEnglish (US)
Pages (from-to)877-882
Number of pages6
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume83
Issue number9
DOIs
StatePublished - Sep 2012
Externally publishedYes

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Multiple Sclerosis
Inversion
Recovery
Lesion
Gray Matter

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Surgery
  • Arts and Humanities (miscellaneous)

Cite this

Sethi, V., Yousry, T. A., Muhlert, N., Ron, M., Golay, X., Wheeler-Kingshott, C., ... Chard, D. (2012). Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI. Journal of Neurology Neurosurgery and Psychiatry, 83(9), 877-882. https://doi.org/10.1136/jnnp-2012-303023

Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI. / Sethi, Varun; Yousry, Tarek A.; Muhlert, Nils; Ron, Maria; Golay, Xavier; Wheeler-Kingshott, Claudia; Miller, David H.; Chard, DeclanT.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 83, No. 9, 09.2012, p. 877-882.

Research output: Contribution to journalArticle

Sethi, V, Yousry, TA, Muhlert, N, Ron, M, Golay, X, Wheeler-Kingshott, C, Miller, DH & Chard, D 2012, 'Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI', Journal of Neurology Neurosurgery and Psychiatry, vol. 83, no. 9, pp. 877-882. https://doi.org/10.1136/jnnp-2012-303023
Sethi, Varun ; Yousry, Tarek A. ; Muhlert, Nils ; Ron, Maria ; Golay, Xavier ; Wheeler-Kingshott, Claudia ; Miller, David H. ; Chard, DeclanT. / Improved detection of cortical MS lesions with phase-sensitive inversion recovery MRI. In: Journal of Neurology Neurosurgery and Psychiatry. 2012 ; Vol. 83, No. 9. pp. 877-882.
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AU - Miller, David H.

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