Improved brain tumor segmentation by utilizing tumor growth model in longitudinal brain MRI

Linmin Pei, Syed M.S. Reza, Wei Li, Christos Davatzikos, Khan M. Iftekharuddin

Research output: Chapter in Book/Report/Conference proceedingConference contribution


In this work, we propose a novel method to improve texture based tumor segmentation by fusing cell density patterns that are generated from tumor growth modeling. To model tumor growth, we solve the reaction-diffusion equation by using Lattice-Boltzmann method (LBM). Computational tumor growth modeling obtains the cell density distribution that potentially indicates the predicted tissue locations in the brain over time. The density patterns is then considered as novel features along with other texture (such as fractal, and multifractal Brownian motion (mBm)), and intensity features in MRI for improved brain tumor segmentation. We evaluate the proposed method with about one hundred longitudinal MRI scans from five patients obtained from public BRATS 2015 data set, validated by the ground truth. The result shows significant improvement of complete tumor segmentation using ANOVA analysis for five patients in longitudinal MR images.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2017
Subtitle of host publicationComputer-Aided Diagnosis
ISBN (Electronic)9781510607132
Publication statusPublished - 2017
Externally publishedYes
EventMedical Imaging 2017: Computer-Aided Diagnosis - Orlando, United States
Duration: Feb 13 2017Feb 16 2017


OtherMedical Imaging 2017: Computer-Aided Diagnosis
CountryUnited States



  • Cell density
  • Lattice-Boltzmann method
  • Longitudinal MRI
  • Reaction-diffusion equation
  • Tumor growth model
  • Tumor segmentation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Pei, L., Reza, S. M. S., Li, W., Davatzikos, C., & Iftekharuddin, K. M. (2017). Improved brain tumor segmentation by utilizing tumor growth model in longitudinal brain MRI. In Medical Imaging 2017: Computer-Aided Diagnosis (Vol. 10134). [101342L] SPIE.